Disease relevance of Madiol

• By contrast, Osborne Mendel male rats were least susceptible to hepatic carcinogenesis and cirrhosis [1].
• The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions [2].
• Morning hypercoagulability and hypofibrinolysis. Diurnal variations in circulating activated factor VII, prothrombin fragment F1+2, and plasmin-plasmin inhibitor complex [3].
• Nonpolarized secretion of human meprin alpha in colorectal cancer generates an increased proteolytic potential in the stroma [4].
• Western blots of a series of 11 paired samples of carcinomas and normal control colon tissue revealed that meprin alpha protein accumulated at significant levels in 6 carcinomas at Union International Contre le Cancer tumor stages I-IV [4].

Psychiatry related information on Madiol

• Effects of meta-chlorophenylpiperazine infusions in patients with seasonal affective disorder and healthy control subjects. Diurnal responses and nocturnal regulatory mechanisms [5].
• For data analysis, mean performance obtained during the day preceding the sleep deprivation night was considered as "Diurnal Baseline" and compared to performance upon awakening from nocturnal sleep [6].
• Psychological stressors as a model of maternal adversity: Diurnal modulation of corticosterone responses and changes in maternal behavior [7].
• Short communication: Diurnal feeding pattern of lactating dairy cows [8].
• AIMS: This study aimed to investigate: (1) the prevalence of BPSD in nursing home residents using the BEHAVE-AD; (2) the relationships of BPSD with (a) demographic, (b) dementia, (c) diurnal and (d) nursing home variables; and (3) the inter-relationships between different types of BPSD, as measured by subscales of the BEHAVE-AD [9].

High impact information on Madiol

• A defect in harmonin, a PDZ domain-containing protein expressed in the inner ear sensory hair cells, underlies Usher syndrome type 1C [10].
• We identified this gene (USH1C), encoding a PDZ-domain-containing protein, harmonin, in a subtracted mouse cDNA library derived from inner ear sensory areas [10].
• We showed that, in the mouse inner ear, only the sensory hair cells express harmonin [10].
• Letter: Diurnal variation of serum beta 2 microglobulin in normal subjects [11].
• Science in culture: peas without pictures--Gregor Mendel and the mathematical birth of modern genetics [12].

Chemical compound and disease context of Madiol

• Re: Diurnal cortisol variations and symptoms in patients with interstitial cystitis [13].
• Response to "Comment on 'Diurnal excretion of urinary cortisol, cortisone, and cortisol metabolites in chronic fatigue syndrome'" by Dr. Fenske [14].

Biological context of Madiol

• Evolutionary genetics. Siberian mice upset Mendel [15].
• Genetic mosaicism: what Gregor Mendel didn't know [16].
• We used the pedigree information to estimate penetrance using the MENDEL program [17].
• Some of the morphological features indicate that aneural regeneration events continuously occur and significantly contribute to the increasing uniformity of the myosin gene expression in long-term denervated diaphragm [18].
• Beyond Mendel: an evolving view of human genetic disease transmission [19].

Anatomical context of Madiol

• Aneural muscle cell cultures make synaptic basal lamina components [20].
• We report here that E/C8-positive mesenchymal cells of the arches can develop into neurones spontaneously in culture, or can migrate into aneural guts with which they are co-cultured and form enteric ganglia [21].
• Acetylcholine hot spots: development on myotubes cultured from aneural limb buds [22].
• A protein fraction isolated from peripheral nerves maintained the level of acetylcholinesterase in cultures of aneural embryonic muscle or denervated adult chicken muscle [23].
• Moreover, we demonstrate that harmonin b is an F-actin-bundling protein, which is thus likely to anchor cadherin 23 to the stereocilia microfilaments, thereby identifying a novel anchorage mode of the cadherins to the actin cytoskeleton [24].

Associations of Madiol with other chemical compounds

• Epithelial cells of the normal human colonic mucosa secrete an astacin-type metalloprotease, meprin a (E. C. 3.4.24.18, N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase), into the intestinal lumen [4].
• Neither the addition of exogenous proteoglycans or conditioned medium from wild-type C2 cells, nor the growth of S27 cells on substrates rich in basal lamina elements caused clusters to appear on S27 myotubes in aneural cultures [25].
• Cysteine mutations in the MAM domain result in monomeric meprin and alter stability and activity of the proteinase [26].
• Analyses of the recombinant homo-oligomeric form of mouse meprin A by gel filtration, nondenaturing gel electrophoresis, and cross-linking (with disuccinimidyl suberate or N-(4-azido-2,3,5,6-tetraflourobenzyl)-3-maleimidylpropionamide) indicate that the secreted enzyme forms high molecular weight multimers, with a predominance of decamers [27].
• Replacement of glycines in the meprin alphaT domain GXXXG motif with leucine residues, alanine insertions in the meprin alphaT domain, and mutagenesis of basic residues within the meprin alphaC domain did not enhance the movement of the alpha subunit through the secretory pathway [28].

Gene context of Madiol

• Deaf-blindness in three distinct genetic forms of Usher type I syndrome (USH1) is caused by defects in myosin VIIa, harmonin and cadherin 23 [24].
• Here we show that harmonin, a PDZ domain-containing protein, and cadherin 23 are both present in the growing stereocilia and that they bind to each other [24].
• We pinpoint these interactions to interactions between the PDZ1 domain of harmonin and the PDZ-binding motifs at the C-termini of the USH2 proteins and NBC3 [29].
• Myosin VIIa and Sans are both involved in the sorting and/or targeting of harmonin b to the stereocilia [30].
• Western blotting with antisera specific to the meprin-alpha and the meprin-beta subunits established that the only form of meprin present in urine samples was derived from meprin-alpha [31].

Analytical, diagnostic and therapeutic context of Madiol

• M-GP mRNA was demonstrated in both aneural and innervated cultures of patients and control by primer extension and PCR amplification of total RNA [32].
• Immunoprecipitation studies, Western blot analyses and other biochemical properties of the purified enzyme confirm that the distinct matrix-degrading enzyme is indeed meprin [33].
• By co-immunoprecipitation and in vitro binding assays, we establish that the usherin cytodomain can bind to whirlin and harmonin, two PDZ domain-containing proteins that are defective in genetic forms of isolated deafness and USH type I, respectively [34].
• The expression of meprin alpha in colorectal cancer was confirmed using Northern blot analysis [4].
• To better characterize the cues guiding this stereotyped axon outgrowth, we have performed a series of transplantation studies in which neurons from a variety of sources (wing, eye, antenna, and leg disks) were placed into mutant, aneural wings [35].

References