Disease relevance of Apbb2

• A novel cDNA, TR2L, isolated from murine NIH 3T3 fibroblasts, was found to modulate tumor necrosis factor (TNF)-mediated apoptosis in murine L929 fibrosarcoma cells [1].

High impact information on Apbb2

• By cDNA library screening, here we isolated an unusual gene transcript encoding a 31-amino-acid zinc finger-like peptide that regulates apoptosis (named Zfra) [2].
• In contrast, TR2L enhanced anti-Fas antibodies/actinomycin D (ActD)-mediated L929 apoptosis [1].
• Functional role of TR2L protein in regulation of cancer cell susceptibility to TNF-and Fas ligand-mediated apoptosis is suggested [1].
• Enhanced cell death also occurred in these 6xH-TR2L-expressing cells under serum starvation conditions [1].
• L929 cells which stably expressed 6xH-TR2L acquired a significantly enhanced TNF apoptotic response and increased genomic DNA fragmentation compared to control cells [1].

Other interactions of Apbb2

• In contrast, the anti-Fas/ActD-mediated apoptosis was blocked by the 6xH-TR2L protein [1].

References