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Gene Review

Apbb2  -  amyloid beta (A4) precursor protein...

Mus musculus

Synonyms: 2310007D03Rik, Amyloid beta A4 precursor protein-binding family B member 2, FE65L1, Rirl1, TR2L, ...
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Disease relevance of Apbb2


High impact information on Apbb2

  • By cDNA library screening, here we isolated an unusual gene transcript encoding a 31-amino-acid zinc finger-like peptide that regulates apoptosis (named Zfra) [2].
  • In contrast, TR2L enhanced anti-Fas antibodies/actinomycin D (ActD)-mediated L929 apoptosis [1].
  • Functional role of TR2L protein in regulation of cancer cell susceptibility to TNF-and Fas ligand-mediated apoptosis is suggested [1].
  • Enhanced cell death also occurred in these 6xH-TR2L-expressing cells under serum starvation conditions [1].
  • L929 cells which stably expressed 6xH-TR2L acquired a significantly enhanced TNF apoptotic response and increased genomic DNA fragmentation compared to control cells [1].

Other interactions of Apbb2


  1. Regulation of tumor necrosis factor-and Fas-mediated apoptotic cell death by a novel cDNA TR2L. Cao, H., Mattison, J., Zhao, Y., Joki, N., Grasso, M., Chang, N.S. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  2. Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Hsu, L.J., Schultz, L., Mattison, J., Lin, Y.S., Chang, N.S. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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