Psychiatry related information on Synpo2

• This may be related to an effect on expression of helix-loop-helix (h-l-h) regulatory molecules since in myoblastic cells, doxorubicin inhibits Myo D expression and enhances Id expression [1].

High impact information on Synpo2

• Expression of Myo X redistributes DCC to the cell periphery or to the tips of neurites, whereas its silencing prevents DCC distribution in neurites [2].
• In muscle cells, myopodin redistributes between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion [3].
• The product of the murine Myo-D1 gene is able to initiate the complete sequence of genetic events required for formation of skeletal muscle [4].
• The biological significance of RFLP of the Myo-D1 gene is yet to be determined [5].
• Genetic polymorphism of the murine myogenic gene Myo-D1 [5].

Biological context of Synpo2

• Methylation and expression of the Myo D1 determination gene [6].
• A gene called Myo D1, recently isolated from such a myoblast line, will confer myogenesis when expressed in 10T1/2 or other cell types (Davis et al. 1987) [6].
• Because efficiency of regeneration of skeletal muscle is more pronounced in SJL/J mice, as compared to other strains, differences in the structure of Myo-D1 and the upstream regulatory region were sought to determine whether efficiency of tissue repair was influenced by the structure of the gene itself [4].
• Induction of Myo D expression in NIH 3T3 cells produces a differentiated myocyte phenotype without passing through a determination-like state [7].

Anatomical context of Synpo2

• The cDNA for Myo D1 contains a large number of CpG sequences and the gene is relatively methylated in 10T1/2 cells and an adipocyte derivative, but is demethylated in myogenic derivatives [6].

References