Gene Review:
DCC - DCC netrin 1 receptor
Homo sapiens
Synonyms:
CRC18, CRCR1, Colorectal cancer suppressor, IGDCC1, Immunoglobulin superfamily DCC subclass member 1, ...
Kato,
Kapitanovic,
Willen,
Baldelli,
Kondoh,
Ringold,
Summers,
Nishimura,
Nilsson,
Fabre,
Asanoma,
Mangeat,
Kedinger,
Staccioli,
Odin,
Marta Ramirez Gaite,
Rossi,
Jannine D. Cody,
Mitros,
Carlsson,
Graziano,
Mangin,
Catalano,
Matsuda,
Catalano,
Latil,
Howe,
Yoshikawa,
Stone,
Muretto,
Cochant-Priollet,
Cussenot,
Berthon,
Lamovec,
Gall-Troselj,
Fournier,
Martin,
Kato,
Pavelic,
Gustavsson,
Cascinu,
Arima,
Martín,
Inoue,
Chêne,
Simon-Assmann,
Wettergren,
Real,
Pavelic,
Giordani,
Novak,
Wake,
- Congenital mirror movements: a clue to understanding bimanual motor control. Galléa, C., Popa, T., Billot, S., Méneret, A., Depienne, C., Roze, E. J. Neurol. (2011)
- Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Hu, G., Zhang, S., Vidal, M., Baer, J.L., Xu, T., Fearon, E.R. Genes Dev. (1997)
- Concordance of genetic alterations in poorly differentiated colorectal neuroendocrine carcinomas and associated adenocarcinomas. Vortmeyer, A.O., Lubensky, I.A., Merino, M.J., Wang, C.Y., Pham, T., Furth, E.E., Zhuang, Z. J. Natl. Cancer Inst. (1997)
- The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction. Bataller, L., Wade, D.F., Graus, F., Rosenfeld, M.R., Dalmau, J. Ann. Neurol. (2003)
- The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma. Maesawa, C., Tamura, G., Suzuki, Y., Ogasawara, S., Sakata, K., Kashiwaba, M., Satodate, R. J. Pathol. (1995)
- The DCC protein and colon cancer. Swaim, M.W. N. Engl. J. Med. (1997)
- Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Keino-Masu, K., Masu, M., Hinck, L., Leonardo, E.D., Chan, S.S., Culotti, J.G., Tessier-Lavigne, M. Cell (1996)
- Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Thiagalingam, S., Lengauer, C., Leach, F.S., Schutte, M., Hahn, S.A., Overhauser, J., Willson, J.K., Markowitz, S., Hamilton, S.R., Kern, S.E., Kinzler, K.W., Vogelstein, B. Nat. Genet. (1996)
- The DCC protein and prognosis in colorectal cancer. Shibata, D., Reale, M.A., Lavin, P., Silverman, M., Fearon, E.R., Steele, G., Jessup, J.M., Loda, M., Summerhayes, I.C. N. Engl. J. Med. (1996)
- Scrambled exons. Nigro, J.M., Cho, K.R., Fearon, E.R., Kern, S.E., Ruppert, J.M., Oliner, J.D., Kinzler, K.W., Vogelstein, B. Cell (1991)
- Activation of FAK and Src are receptor-proximal events required for netrin signaling. Li, W., Lee, J., Vikis, H.G., Lee, S.H., Liu, G., Aurandt, J., Shen, T.L., Fearon, E.R., Guan, J.L., Han, M., Rao, Y., Hong, K., Guan, K.L. Nat. Neurosci. (2004)
- Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells. Ugai, H., Li, H.O., Komatsu, M., Tsutsui, H., Song, J., Shiga, T., Fearon, E., Murata, T., Yokoyama, K.K. Biochem. Biophys. Res. Commun. (2001)
- Folic acid mediated attenuation of loss of heterozygosity of DCC tumor suppressor gene in the colonic mucosa of patients with colorectal adenomas. Nagothu, K.K., Jaszewski, R., Moragoda, L., Rishi, A.K., Finkenauer, R., Tobi, M., Naumoff, J.A., Dhar, R., Ehrinpreis, M., Kucuk, O., Majumdar, A.P. Cancer Detect. Prev. (2003)
- Deleted in colorectal carcinoma (DCC) binds heparin via its fifth fibronectin type III domain. Bennett, K.L., Bradshaw, J., Youngman, T., Rodgers, J., Greenfield, B., Aruffo, A., Linsley, P.S. J. Biol. Chem. (1997)
- Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients. Wettergren, Y., Odin, E., Nilsson, S., Willen, R., Carlsson, G., Gustavsson, B. Cancer Detect. Prev. (2005)
- Focal adhesion kinase in netrin-1 signaling. Ren, X.R., Ming, G.L., Xie, Y., Hong, Y., Sun, D.M., Zhao, Z.Q., Feng, Z., Wang, Q., Shim, S., Chen, Z.F., Song, H.J., Mei, L., Xiong, W.C. Nat. Neurosci. (2004)
- Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth. Xie, Y., Ding, Y.Q., Hong, Y., Feng, Z., Navarre, S., Xi, C.X., Zhu, X.J., Wang, C.L., Ackerman, S.L., Kozlowski, D., Mei, L., Xiong, W.C. Nat. Cell Biol. (2005)
- Genetic alterations in sporadic and Crohn's-associated adenocarcinomas of the small intestine. Rashid, A., Hamilton, S.R. Gastroenterology (1997)
- A gene for familial juvenile polyposis maps to chromosome 18q21.1. Howe, J.R., Ringold, J.C., Summers, R.W., Mitros, F.A., Nishimura, D.Y., Stone, E.M. Am. J. Hum. Genet. (1998)
- Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC. de la Torre, J.R., Höpker, V.H., Ming, G.L., Poo, M.M., Tessier-Lavigne, M., Hemmati-Brivanlou, A., Holt, C.E. Neuron (1997)
- Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal. Tsai, H.H., Tessier-Lavigne, M., Miller, R.H. Development (2003)
- DCC regulates cell adhesion in human colon cancer derived HT-29 cells and associates with ezrin. Martín, M., Simon-Assmann, P., Kedinger, M., Martin, M., Mangeat, P., Real, F.X., Fabre, M. Eur. J. Cell Biol. (2006)
- Collision tumour in the pelvic cavity: rectal leiomyosarcoma and prostate adenocarcinoma. Pavelic, J., Lamovec, J., Novak, J., Gall-Troselj, K., Kapitanovic, S., Pavelic, K. J. Cancer Res. Clin. Oncol. (2000)
- Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin. Geisbrecht, B.V., Dowd, K.A., Barfield, R.W., Longo, P.A., Leahy, D.J. J. Biol. Chem. (2003)
- DCC association with lipid rafts is required for netrin-1-mediated axon guidance. Hérincs, Z., Corset, V., Cahuzac, N., Furne, C., Castellani, V., Hueber, A.O., Mehlen, P. J. Cell. Sci. (2005)
- Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor. Corset, V., Nguyen-Ba-Charvet, K.T., Forcet, C., Moyse, E., Chédotal, A., Mehlen, P. Nature (2000)
- Mediation of the DCC apoptotic signal by DIP13 alpha. Liu, J., Yao, F., Wu, R., Morgan, M., Thorburn, A., Finley, R.L., Chen, Y.Q. J. Biol. Chem. (2002)
- Quantification of expression of netrins, slits and their receptors in human prostate tumors. Latil, A., Chêne, L., Cochant-Priollet, B., Mangin, P., Fournier, G., Berthon, P., Cussenot, O. Int. J. Cancer (2003)
- Potential role and chronology of abnormal expression of the Deleted in Colon Cancer (DCC) and the p53 proteins in the development of gastric cancer. Graziano, F., Cascinu, S., Staccioli, M.P., Catalano, V., Rossi, M.C., Baldelli, A.M., Giordani, P., Muretto, P., Catalano, G. BMC Cancer (2001)
- p53, DCC and thymidylate synthase as predictors of survival after resection of hepatic metastases from colorectal cancer. Saw, R.P., Koorey, D., Painter, D., Gallagher, P.J., Solomon, M.J. The British journal of surgery. (2002)
- Bcl-2 expression and allelic loss of the p53 gene in gastric carcinomas. Saegusa, M., Takano, Y., Kamata, Y., Okayasu, J. J. Cancer Res. Clin. Oncol. (1996)
- Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron. Kim, T.H., Lee, H.K., Seo, I.A., Bae, H.R., Suh, D.J., Wu, J., Rao, Y., Hwang, K.G., Park, H.T. J. Neurochem. (2005)
- Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene. Velcich, A., Corner, G., Palumbo, L., Augenlicht, L. Oncogene (1999)
- Allelic loss and somatic differentiation in human male germ cell tumors. Murty, V.V., Bosl, G.J., Houldsworth, J., Meyers, M., Mukherjee, A.B., Reuter, V., Chaganti, R.S. Oncogene (1994)
- Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. Qin, S., Yu, L., Gao, Y., Zhou, R., Zhang, C. Mol. Cell. Neurosci. (2007)
- Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis. Kato, H.D., Kondoh, H., Inoue, T., Asanoma, K., Matsuda, T., Arima, T., Kato, K., Yoshikawa, T., Wake, N. Gynecol. Oncol. (2004)
- Prognostic significance of the deleted in colorectal cancer gene protein expression in high-risk resected gastric carcinoma. Bamias, A.T., Bai, M.C., Agnantis, N.J., Michael, M.C., Alamanos, Y.P., Stefanaki, S.V., Razi, E.D., Skarlos, D.V., Kappas, A.M., Pavlidis, N.A. Cancer Invest. (2003)
- Evaluation of genetic mutations of tumor suppresser genes in colorectal cancer patients. Kubo, H., Miki, C., Kusunoki, M. Hepatogastroenterology (2004)
- Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues. Reale, M.A., Hu, G., Zafar, A.I., Getzenberg, R.H., Levine, S.M., Fearon, E.R. Cancer Res. (1994)