High impact information on SPIC

• The Ets transcription factor Spi-C, expressed in B cells and macrophages, is closely related to PU.1 and has the ability to recognize the same DNA consensus sequence [1].
• Mouse SPI-C is an SPI-group ETS protein expressed temporarily during B-cell development and in macrophages [2].
• Human SPI-C mRNA is preferentially detected in foetal and adult spleen, lymph nodes and at lower levels in bone marrow and foetal liver [2].
• SPI-C is a novel ETS protein that is expressed in B lymphocytes [3].
• Thus, a protein interaction between SPI-C and STAT6 is the basis for a novel mechanism for regulation of IL4 induced gene expression [3].

Biological context of SPIC

• By deletion and mutation analysis we show that the SPI-C protein has a transactivation domain located to the N-terminus, and that the transactivation activity is reduced to that of the DNA binding domain (DBD) alone when four aspartic acid residues are mutated to alanines [4].

Anatomical context of SPIC

• Spectroscopic analysis showed that White Prosperity root exudate differs from Spic Span root exudate by a higher relative amount of the aromatic-phenolic and sugarlike components and a lower relative amount of carbonylic and aliphatic compounds [5].

Associations of SPIC with chemical compounds

• Long-term survival effect of metoprolol in dilated cardiomyopathy. The SPIC (Italian Multicentre Cardiomyopathy Study) Group [6].

Analytical, diagnostic and therapeutic context of SPIC

• By co-immunoprecipitation in transfected COS7 cells the physical interaction between SPI-C and STAT6 was confirmed [3].

References