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Gene Review

ABCG1  -  ATP-binding cassette, sub-family G (WHITE)...

Homo sapiens

Synonyms: ABC8, ATP-binding cassette sub-family G member 1, ATP-binding cassette transporter 8, WHITE1, WHT1, ...
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Disease relevance of ABCG1


Psychiatry related information on ABCG1

  • A single haplotype was shared by all affected individuals and informative crossovers indicated that the elusive gene that confers susceptibility to narcolepsy is likely to be located between markers D21S267 and ABCG1, in a 5.15 Mb region of 21q [6].
  • Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder [7].
  • BACKGROUND: White-matter hyperintensities are commonly found on magnetic resonance imaging (MRI) of elderly people with or without dementia [8].
  • SETTING: Weill-Cornell Medical Center, White Plains, NY; University of Minnesota, Minneapolis; and Stanford University, Stanford, Calif.Patients One hundred twenty-two patients meeting DSM-IV criteria for anorexia nervosa [9].
  • However, a meta-analytic synthesis of 261 comparisons, based largely on self-esteem scales and involving more than half a million respondents, revealed higher scores for Black than for White children, adolescents, and young adults [10].

High impact information on ABCG1

  • Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System [11].
  • Cord levels of C peptide in infants of diabetic mothers were elevated at the earliest gestational age studied (less than 34 weeks) and were directly related to the severity of maternal diabetes, as assessed by the White classification [12].
  • Row over White House moves to ban fetal tissue research [13].
  • Biotechnology regulation: White House holds the ring [14].
  • A uranium-lead zircon age for a volcanic ash interstratified with fossil-bearing, shallow marine siliciclastic rocks in the Zimnie Gory section of the White Sea region indicates that a diverse assemblage of body and trace fossils occurred before 555.3 +/- 0.3 million years ago [15].

Chemical compound and disease context of ABCG1

  • In this study, we performed detailed molecular analyses of a series of C. albicans isolates from an MT patient who developed disseminated candidiasis caused by an azole-resistant strain 2 weeks after initiation of fluconazole prophylaxis (K. A. Marr, T. C. White, J. A. H. vanBurik, and R. A. Bowden, Clin. Infect. Dis. 25:908-910, 1997) [16].
  • Serum samples were collected from 20 healthy White and 33 Black infants before and after immunisation with three doses of diphtheria-pertussis-tetanus vaccine and with one dose of Haemophilus influenzae type b polyribose phosphate vaccine and meningococcal group A and group C polysaccharide vaccines [17].
  • In an attempt to resolve this apparent disagreement, we exposed White Carneau pigeons to drinking water containing calcium (100 ppm), magnesium (30 ppm), lead (0.8 ppm), or cadmium (0.6 ppm) and used a 2(4)-factorial design to measure the effects of these elements in atherosclerosis and hypertension [18].
  • The relationship of the increased urinary excretion of steroid hormones in Black South African men, a low-risk group fed a Western diet, and the decreased excretion in Black and White North American men, high-risk groups fed a vegetarian diet, to the development of prostatic cancer remains to be clarified [19].
  • Human choriocarcinoma cells (JAR) synthesize the alpha and beta subunits of the glycoprotein hormone chorionic gonadotropin (hCG) (R.W. Ruddon, C.A. Hanson, A. H. Bryan, G.J. Putterman, E.L. White, F. Perini, K. S. Meade, and P.H. Aldenderfer (1980) J. Biol. Chem. 255, 1000-1007) [20].

Biological context of ABCG1


Anatomical context of ABCG1

  • Immunocytochemical and flow cytometric analyses revealed that ABCG1 is expressed on the cell surface and in intracellular compartments of cholesterol-laden macrophages [25].
  • ABCG1, another LXR target gene involved in cholesterol efflux to HDL, also showed diminished expression in NPC1(-/-) fibroblasts and increased expression upon LXR agonist treatment [26].
  • Treatment of Caco-2 cells with bile acids, which activate farnesoid X receptor and subsequently induce SHP, leads to the repression of the human ABCG1 gene, an established LXR target gene [27].
  • To determine if such HDL reduction correlates with a change in ABCA1 or ABCG1 expression, their expressions were measured in THP-1 monocytes and mice treated with LPS [28].
  • The ABCG1 gene is induced in endothelial cells by cholesterol, whereas ABCA1 is not [29].

Associations of ABCG1 with chemical compounds


Physical interactions of ABCG1


Regulatory relationships of ABCG1

  • HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway [34].
  • Interestingly in this study, the linkage evidence on 11 p at the SUR locus was somewhat enhanced (lod score went up from 1.7 to 2.0) in a prehypertensive (BP >or= 135/80 mm Hg) subset of 40 White families suggesting a pleiotropic gene for BP and RHR with interactions [35].
  • The prevalence of the homozygous IGF1 (CA)(19) genotype was much lower in Black controls (21%) than White controls (46%), which may, in part, explain the increased prostate cancer incidence in Black versus White men [36].
  • We examined the prevalence and predictors of BRCA1 and BRCA2 mutations in 1,628 women with breast cancer and 674 women without breast cancer who participated in a multicenter population-based case-control study of Black and White women, 35 to 64 years of age [37].
  • New Zealand White rabbits that received intra-articular injections of Ad.RSVIL-1ra expressed transgenic IL-1ra in synoviocytes, and secretion was detected for at least 4 weeks post-infection [38].

Other interactions of ABCG1


Analytical, diagnostic and therapeutic context of ABCG1


  1. Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease. Lorkowski, S., Kratz, M., Wenner, C., Schmidt, R., Weitkamp, B., Fobker, M., Reinhardt, J., Rauterberg, J., Galinski, E.A., Cullen, P. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  2. Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene. Langmann, T., Porsch-Ozcürümez, M., Unkelbach, U., Klucken, J., Schmitz, G. Biochim. Biophys. Acta (2000) [Pubmed]
  3. The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver. Sabol, S.L., Brewer, H.B., Santamarina-Fojo, S. J. Lipid Res. (2005) [Pubmed]
  4. Physiological function of ABCG1. Ito, T. Drug News Perspect. (2003) [Pubmed]
  5. The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. Kim, M., Turnquist, H., Jackson, J., Sgagias, M., Yan, Y., Gong, M., Dean, M., Sharp, J.G., Cowan, K. Clin. Cancer Res. (2002) [Pubmed]
  6. A narcolepsy susceptibility locus maps to a 5 Mb region of chromosome 21q. Dauvilliers, Y., Blouin, J.L., Neidhart, E., Carlander, B., Eliaou, J.F., Antonarakis, S.E., Billiard, M., Tafti, M. Ann. Neurol. (2004) [Pubmed]
  7. Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder. Kirov, G., Lowry, C.A., Stephens, M., Oldfield, S., O'Donovan, M.C., Lightman, S.L., Owen, M.J. Mol. Psychiatry (2001) [Pubmed]
  8. Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study. Garde, E., Mortensen, E.L., Krabbe, K., Rostrup, E., Larsson, H.B. Lancet (2000) [Pubmed]
  9. Predictors of treatment acceptance and completion in anorexia nervosa: implications for future study designs. Halmi, K.A., Agras, W.S., Crow, S., Mitchell, J., Wilson, G.T., Bryson, S.W., Kraemer, H.C. Arch. Gen. Psychiatry (2005) [Pubmed]
  10. Factors influencing racial comparisons of self-esteem: a quantitative review. Gray-Little, B., Hafdahl, A.R. Psychological bulletin. (2000) [Pubmed]
  11. Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System. Sarkadi, B., Homolya, L., Szak??cs, G., V??radi, A. Physiol. Rev. (2006) [Pubmed]
  12. The infant of the diabetic mother: correlation of increased cord C-peptide levels with macrosomia and hypoglycemia. Sosenko, I.R., Kitzmiller, J.L., Loo, S.W., Blix, P., Rubenstein, A.H., Gabbay, K.H. N. Engl. J. Med. (1979) [Pubmed]
  13. Row over White House moves to ban fetal tissue research. Palca, J. Nature (1988) [Pubmed]
  14. Biotechnology regulation: White House holds the ring. Beardsley, T. Nature (1985) [Pubmed]
  15. Age of Neoproterozoic bilatarian body and trace fossils, White Sea, Russia: implications for metazoan evolution. Martin, M.W., Grazhdankin, D.V., Bowring, S.A., Evans, D.A., Fedonkin, M.A., Kirschvink, J.L. Science (2000) [Pubmed]
  16. Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR. Marr, K.A., Lyons, C.N., Rustad, T.R., Bowden, R.A., White, T.C., Rustad, T. Antimicrob. Agents Chemother. (1998) [Pubmed]
  17. Association between immunoglobulin allotypes and immune responses to Haemophilus influenzae and Meningococcus polysaccharides. Pandey, J.P., Fudenberg, H.H., Virella, G., Kyong, C.U., Loadholt, C.B., Galbraith, R.M., Gotschlich, E.C., Parke, J.C. Lancet (1979) [Pubmed]
  18. Atherosclerosis and hypertension induction by lead and cadmium ions: an effect prevented by calcium ion. Revis, N.W., Zinsmeister, A.R., Bull, R. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  19. Diet and urinary steroids in black and white North American men and black South African men. Hill, P., Wynder, E.L., Garbaczewski, L., Garnes, H., Walker, A.R. Cancer Res. (1979) [Pubmed]
  20. A kinetic comparison of the processing and secretion of the alpha beta dimer and the uncombined alpha and beta subunits of chorionic gonadotropin synthesized by human choriocarcinoma cells. Peters, B.P., Krzesicki, R.F., Hartle, R.J., Perini, F., Ruddon, R.W. J. Biol. Chem. (1984) [Pubmed]
  21. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Wang, N., Lan, D., Chen, W., Matsuura, F., Tall, A.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  22. ATP-binding cassette transporter G1 and lipid homeostasis. Baldán, A., Tarr, P., Lee, R., Edwards, P.A. Curr. Opin. Lipidol. (2006) [Pubmed]
  23. The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux. Porsch-Ozcurumez, M., Langmann, T., Heimerl, S., Borsukova, H., Kaminski, W.E., Drobnik, W., Honer, C., Schumacher, C., Schmitz, G. J. Biol. Chem. (2001) [Pubmed]
  24. Role of ABCG1 and other ABCG family members in lipid metabolism. Schmitz, G., Langmann, T., Heimerl, S. J. Lipid Res. (2001) [Pubmed]
  25. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Klucken, J., Büchler, C., Orsó, E., Kaminski, W.E., Porsch-Ozcürümez, M., Liebisch, G., Kapinsky, M., Diederich, W., Drobnik, W., Dean, M., Allikmets, R., Schmitz, G. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  26. Correction of Apolipoprotein A-I-mediated Lipid Efflux and High Density Lipoprotein Particle Formation in Human Niemann-Pick Type C Disease Fibroblasts. Boadu, E., Choi, H.Y., Lee, D.W., Waddington, E.I., Chan, T., Asztalos, B., Vance, J.E., Chan, A., Castro, G., Francis, G.A. J. Biol. Chem. (2006) [Pubmed]
  27. The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity. Brendel, C., Schoonjans, K., Botrugno, O.A., Treuter, E., Auwerx, J. Mol. Endocrinol. (2002) [Pubmed]
  28. Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway. Kaplan, R., Gan, X., Menke, J.G., Wright, S.D., Cai, T.Q. J. Lipid Res. (2002) [Pubmed]
  29. Cellular physiology of cholesterol efflux in vascular endothelial cells. O'Connell, B.J., Denis, M., Genest, J. Circulation (2004) [Pubmed]
  30. Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. Suzuki, S., Nishimaki-Mogami, T., Tamehiro, N., Inoue, K., Arakawa, R., Abe-Dohmae, S., Tanaka, A.R., Ueda, K., Yokoyama, S. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  31. LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. Murthy, S., Born, E., Mathur, S.N., Field, F.J. J. Lipid Res. (2002) [Pubmed]
  32. Linear epitopes of two different autoantigens-La/SSB and myelin basic protein--with a high degree of molecular similarity, cause different humoral immune responses. Terzoglou, A.G., Routsias, J.G., Sakarellos, C., Sakarellos-Daitsiotis, M., Moutsopoulos, H.M., Tzioufas, A.G. J. Autoimmun. (2003) [Pubmed]
  33. Study of the pH-Dependent Conformational Changes in {alpha}1-Acid Glycoprotein Using FRET. Mikhailov, A.S. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  34. HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway. Matsuura, F., Wang, N., Chen, W., Jiang, X.C., Tall, A.R. J. Clin. Invest. (2006) [Pubmed]
  35. Genome-wide scan to identify quantitative trait loci for baseline resting heart rate and its response to endurance exercise training: the HERITAGE Family Study. An, P., Rice, T., Rankinen, T., Leon, A.S., Skinner, J.S., Wilmore, J.H., Bouchard, C., Rao, D.C. International journal of sports medicine. (2006) [Pubmed]
  36. IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men. Schildkraut, J.M., Demark-Wahnefried, W., Wenham, R.M., Grubber, J., Jeffreys, A.S., Grambow, S.C., Marks, J.R., Moorman, P.G., Hoyo, C., Ali, S., Walther, P.J. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
  37. Prevalence and Predictors of BRCA1 and BRCA2 Mutations in a Population-Based Study of Breast Cancer in White and Black American Women Ages 35 to 64 Years. Malone, K.E., Daling, J.R., Doody, D.R., Hsu, L., Bernstein, L., Coates, R.J., Marchbanks, P.A., Simon, M.S., McDonald, J.A., Norman, S.A., Strom, B.L., Burkman, R.T., Ursin, G., Deapen, D., Weiss, L.K., Folger, S., Madeoy, J.J., Friedrichsen, D.M., Suter, N.M., Humphrey, M.C., Spirtas, R., Ostrander, E.A. Cancer Res. (2006) [Pubmed]
  38. Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector. Roessler, B.J., Hartman, J.W., Vallance, D.K., Latta, J.M., Janich, S.L., Davidson, B.L. Hum. Gene Ther. (1995) [Pubmed]
  39. ATP-binding cassette (ABC) transporters in human metabolism and diseases. Stefková, J., Poledne, R., Hubácek, J.A. Physiological research / Academia Scientiarum Bohemoslovaca. (2004) [Pubmed]
  40. ATP-binding cassette, subfamily G (ABCG family). Kusuhara, H., Sugiyama, Y. Pflugers Arch. (2007) [Pubmed]
  41. ZNF202 is inversely regulated with its target genes ABCA1 and apoE during macrophage differentiation and foam cell formation. Langmann, T., Schumacher, C., Morham, S.G., Honer, C., Heimerl, S., Moehle, C., Schmitz, G. J. Lipid Res. (2003) [Pubmed]
  42. The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache. Schürks, M., Kurth, T., Geissler, I., Tessmann, G., Diener, H.C., Rosskopf, D. Cephalalgia : an international journal of headache (2007) [Pubmed]
  43. Molecular cloning and endometrial expression of porcine high density lipoprotein receptor SR-BI during the estrous cycle and early pregnancy. Kim, J.G., Vallet, J.L., Nonneman, D., Christenson, R.K. Mol. Cell. Endocrinol. (2004) [Pubmed]
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