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Gene Review

Bnip3  -  BCL2/adenovirus E1B interacting protein 3

Mus musculus

Synonyms: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, Nip3
 
 
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Disease relevance of Bnip3

 

High impact information on Bnip3

  • A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis [2].
  • The expression of PLAGL2 in Balb/c3T3 cells led to the mRNA expression of a proapoptotic factor, Nip3, which can dimerize with Bcl-2 [2].
  • Nip3 mRNA was also induced in desferrioxamine-treated cells [2].
  • The transfection of antisense oligonucleotide to mouse Nip3 mRNA into PLAGL2-expressing cells led to a decrease in apoptotic cells compared with sense oligonucleotide-transfected cells [2].
  • Human Nip3 maps to chromosome 14q11.2-q12, whereas Nix/BNip3L was found on 8q21 [3].
 

Biological context of Bnip3

References

  1. Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice. Diwan, A., Krenz, M., Syed, F.M., Wansapura, J., Ren, X., Koesters, A.G., Li, H., Kirshenbaum, L.A., Hahn, H.S., Robbins, J., Jones, W.K., Dorn, G.W. J. Clin. Invest. (2007) [Pubmed]
  2. A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis. Mizutani, A., Furukawa, T., Adachi, Y., Ikehara, S., Taketani, S. J. Biol. Chem. (2002) [Pubmed]
  3. Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. Chen, G., Cizeau, J., Vande Velde, C., Park, J.H., Bozek, G., Bolton, J., Shi, L., Dubik, D., Greenberg, A. J. Biol. Chem. (1999) [Pubmed]
  4. Gene expression analysis in HBV transgenic mouse liver: a model to study early events related to hepatocarcinogenesis. Barone, M., Spano, D., D'Apolito, M., Centra, M., Lasalandra, C., Capasso, M., Di Leo, A., Volinia, S., Arcelli, D., Rosso, N., Francavilla, A., Tiribelli, C., Iolascon, A. Mol. Med. (2006) [Pubmed]
 
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