High impact information on C6

• C57BL/6 female mice immunized with male cells were the source of memory T cells, whereas C6 mice transgenic for HY-specific T-cell receptor provided naive T cells [1].
• Bands of C6 hemolytic activity in the washed resolving gel were identified by means of an erythrocyte/agarose overlay gel [2].
• However, alcohol specifically compromised the heart and caudal neural tube in C6, whereas it specifically decreased the number of somites and the development of branchial bars among others in D2 [3].
• Testing C6 allotypes in a limited number of wild mice revealed that haplotypes found in inbred strains of Western or Eastern origin tend to reflect haplotypes of the wild mice from Europe or Japan, respectively [4].
• Plasma C6 was analyzed by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and by isoelectric focusing (IEF), and C6 band patterns were developed by electroblotting and immunoprobing [4].

Biological context of C6

• Assignment of the gene locus for the sixth component (C6) of complement in mice to chromosome 15 [5].
• Genetic polymorphism of the sixth component of complement (C6) in mice [6].
• Thus, a total of four different mouse C6 haplotypes have been identified [4].

Associations of C6 with chemical compounds

• The gene apparently requires androgen to facilitate C6 production in the majority of strains [7].

Other interactions of C6

• Close linkage between mouse genes determining the two forms of complement component C6 and component C7, and cis action of a C6 regulatory gene [7].

Analytical, diagnostic and therapeutic context of C6

• Immunofixation after isoelectric focusing revealed two forms of mouse C6, C6A and C6M, both of which consist of two major protein bands and one or more acidic minor bands [6].

References