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Gene Review

PRSS29P  -  protease, serine, 29, pseudogene

Homo sapiens

Synonyms: ISP2, ISP2-like protein, Implantation serine proteinase 2-like protein, Isp2
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Disease relevance of PRSS29P

  • ISP1 and ISP2 are homologous to ORF5 and ORF6 in the hmc operon, coding for a transmembrane electron transfer complex in Desulfovibrio vulgaris [1].

High impact information on PRSS29P

  • This IS harbors two sequential open reading frames (ORFs) which may code for electron transfer proteins ISP1 and ISP2 [1].
  • Menaquinone composition varied with the medium used for cell cultivation; on glucose-yeast extract medium supplemented with 10 % NaCl, the major menaquinone was MK-9(H(4)), while, on vitamin-enriched ISP 2 medium, the major menaquinones were MK-10(H(2)), MK-9(H(8)) and MK-10(H(4)) [2].
  • Production of overall antifungal and antibacterial activities was checked on the complex medium ISP2 and a synthetic medium (SM) that contains glucose or starch as carbon source, and ammonium or nitrate as nitrogen source [3].
  • BACKGROUND: We have recently reported the expression of murine Implantation Serine Proteinase genes in pre-implantation embryos (ISP1) and uterus (ISP1 and ISP2) [4].

Anatomical context of PRSS29P

  • In addition to being co-expressed in uterus, we show that ISP1 and ISP2 are also co-expressed in the pre-implantation embryo [4].


  1. Unusual organization of the genes coding for HydSL, the stable [NiFe]hydrogenase in the photosynthetic bacterium Thiocapsa roseopersicina BBS. Rakhely, G., Colbeau, A., Garin, J., Vignais, P.M., Kovacs, K.L. J. Bacteriol. (1998) [Pubmed]
  2. Streptomonospora alba sp. nov., a novel halophilic actinomycete, and emended description of the genus Streptomonospora Cui et al. 2001. Li, W.J., Xu, P., Zhang, L.P., Tang, S.K., Cui, X.L., Mao, P.H., Xu, L.H., Schumann, P., Stackebrandt, E., Jiang, C.L. Int. J. Syst. Evol. Microbiol. (2003) [Pubmed]
  3. Nocardiopsis and Saccharothrix genera in Saharan soils in Algeria: isolation, biological activities and partial characterization of antibiotics. Zitouni, A., Boudjella, H., Lamari, L., Badji, B., Mathieu, F., Lebrihi, A., Sabaou, N. Res. Microbiol. (2005) [Pubmed]
  4. Implantation Serine Proteinases heterodimerize and are critical in hatching and implantation. Sharma, N., Liu, S., Tang, L., Irwin, J., Meng, G., Rancourt, D.E. BMC Dev. Biol. (2006) [Pubmed]
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