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Gene Review:

yopB - translocator YopB

Yersinia enterocolitica W22703

Håkansson, S. et al., Frithz-Lindsten, E. et al., Wattiau, P. et al.

Frithz-Lindsten, Holmström, Jacobsson, Soltani, Olsson, Rosqvist, Forsberg,

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Disease relevance of yopB

Expression of the pcrGVHpopBD operon in defined translocation-deficient mutants (yopB/yopD) of Yersinia resulted in complete complementation of the cell contact-dependent, YopE-induced cytotoxicity of Y. pseudotuberculosis on HeLa cells [1].

High impact information on yopB

A non-polar yopB mutant strain displays a wild-type phenotype with respect to in vitro Yop regulation and secretion but fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells [2].
We also engineered a mutation in lcrH, the gene upstream from yopB and yopD, known to encode a 19-kDa acidic protein [3].

References

Functional conservation of the effector protein translocators PopB/YopB and PopD/YopD of Pseudomonas aeruginosa and Yersinia pseudotuberculosis. Frithz-Lindsten, E., Holmström, A., Jacobsson, L., Soltani, M., Olsson, J., Rosqvist, R., Forsberg, A. Mol. Microbiol. (1998) [Pubmed]
The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity. Håkansson, S., Schesser, K., Persson, C., Galyov, E.E., Rosqvist, R., Homblé, F., Wolf-Watz, H. EMBO J. (1996) [Pubmed]
Individual chaperones required for Yop secretion by Yersinia. Wattiau, P., Bernier, B., Deslée, P., Michiels, T., Cornelis, G.R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]

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