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Gene Review:

yopO - YopO

Yersinia enterocolitica

Logsdon, L.K. et al., Letzelter, M. et al., Grosdent, N. et al., Aepfelbacher, M., Cornelis, G.R.

Cornelis, Aepfelbacher,

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Disease relevance of yopO

Here, we describe and characterize SycO, a new chaperone for the Yersinia effector kinase YopO [1].

High impact information on yopO

The chaperone-binding domain (CBD) within YopO coincides with the membrane localization domain (MLD) targeting YopO to the host cell membrane [1].
Less is known about the role of the phosphoserine kinase YopO/YpkA and YopM [2].
YopE, YopT, and YpkA/YopO modulate the activity of Rho GTP-binding proteins, whereas YopH dephosphorylates phospho-tyrosine residues in focal adhesion proteins [3].
In competition infections with wild-type Y. pseudotuberculosis, the presence of wild-type bacteria severely hindered the ability of the yopH, yopE, and yopO mutants to persist in many tissues, suggesting that the wild-type bacteria either fills colonization niches or elicits host responses that the yop mutants are unable to withstand [4].
These results show that YopH, YopT, YopO, and, in some instances, YopE act synergistically to increase the resistance of Y. enterocolitica to phagocytosis by macrophages and PMNs [5].

References

The discovery of SycO highlights a new function for type III secretion effector chaperones. Letzelter, M., Sorg, I., Mota, L.J., Meyer, S., Stalder, J., Feldman, M., Kuhn, M., Callebaut, I., Cornelis, G.R. EMBO J. (2006) [Pubmed]
Molecular and cell biology aspects of plague. Cornelis, G.R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
Modulation of Rho GTPases by type III secretion system translocated effectors of Yersinia. Aepfelbacher, M. Rev. Physiol. Biochem. Pharmacol. (2004) [Pubmed]
Requirement of the Yersinia pseudotuberculosis effectors YopH and YopE in colonization and persistence in intestinal and lymph tissues. Logsdon, L.K., Mecsas, J. Infect. Immun. (2003) [Pubmed]
Role of Yops and adhesins in resistance of Yersinia enterocolitica to phagocytosis. Grosdent, N., Maridonneau-Parini, I., Sory, M.P., Cornelis, G.R. Infect. Immun. (2002) [Pubmed]

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