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Gene Review

Cd37  -  CD37 antigen

Mus musculus

Synonyms: Leukocyte antigen CD37, Tspan26
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Disease relevance of Cd37

  • In contrast, the non-Hodgkin's lymphoma cell line, OCI.LY1, which is growth-dependent on human serum, carries a CD37 antigen with an additional carbohydrate chain resulting in a total molecular mass of approximately 40 to 64 kDa [1].

High impact information on Cd37

  • Biochemical analysis showed that the CD37 antigen derived from B cell-lines BJAB and LICR-LON-HMy2 consists of a single chain protein core of approximately 25 kDa to which two N-linked, complex carbohydrate antennae of various length are bound [1].
  • We found that, both due to its peculiar biochemical structure and its ultrastructural distribution, the CD37 antigen closely resembles the 46-kDa species of the mannose 6-phosphate receptor [1].
  • The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein [1].
  • The CD37 antigen is strongly expressed on surface immunoglobulin positive B lymphocytes and weakly on a subpopulation of T lymphocytes and myeloid cells [1].
  • Cd37 shows a striking similarity in genomic organisation to other members of the TM4SF, which is consistent with the theory that this superfamily has evolved by gene duplication and divergence from a common ancestral gene [2].


  1. The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein. Schwartz-Albiez, R., Dörken, B., Hofmann, W., Moldenhauer, G. J. Immunol. (1988) [Pubmed]
  2. Characterisation of mouse CD37: cDNA and genomic cloning. Tomlinson, M.G., Wright, M.D. Mol. Immunol. (1996) [Pubmed]
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