Disease relevance of CD37

• CD53 and CD37 were not detected on melanoma [1].
• Delivery of saporin to human B-cell lymphoma using bispecific antibody: targeting via CD22 but not CD19, CD37, or immunoglobulin results in efficient killing [2].
• METHODS: To establish a molecular diagnosis of beta-thalassemia in a second-trimester fetus from a couple who are beta-thalassemia carriers, a rapid real-time PCR method was performed to detect major mutations prevalent in people of the Mediterranean basin (IVS I-1, IVS I-6, IVS I-110, CD-6, CD-37, and CD-39) [3].

High impact information on CD37

• These target antigen restriction was not observed with mononuclear effector cells, which mediated cytotoxicity with antibodies to HLA class II, but also with mouse/human chimeric constructs to CD19, CD37, and CD38 [4].
• BglII restriction fragment length polymorphism at the gene locus coding for the leukocyte surface antigen CD37 [5].
• Simultaneous expression of B-cell (CD19+, CD20+, CD23+, CD37+) and T-cell (CD2+, CD3+/-, CD7+, CD43+) antigens, activation antigens (CD30+, CDw70+) as well as CD68+, a macrophage-associated antigen, was observed on the cell line and its source [6].
• TAPA-1 showed strong homology with the CD37 leukocyte antigen and with the ME491 melanoma-associated antigen, both of which have been implicated in the regulation of cell growth [7].
• In vitro studies measuring inhibition of [3H]leucine uptake by cultured Daudi and Raji cells demonstrated that, despite all BsAb capturing saporin on the cell surface, BsAb targeting through CD22 were far more cytotoxic than those functioning via CD19, CD37, or surface immunoglobulin [2].

Biological context of CD37

• Hyperproliferation was not due to differences in memory to naive T cell ratios in CD37(-/-) mice, apoptosis, or TCR down-modulation [8].
• It appears to lack a conventional leader sequence because the deduced NH2-terminal amino acid sequence is very similar to the rat MRC OX-44 and human CD37 antigens [9].
• The CD37, CD53, and R2 genes were assigned with the help of human/rodent somatic cell hybrids and human-specific probes to human chromosomes 19, 1, and 11, respectively [10].
• Furthermore, transfection of CD37 into a macrophage cell line elevated endogenous dectin-1 surface expression [11].
• Three B-cell cases expressing surface immunoglobulin (sIg) and/or CD37 and one case not analysed phenotypically showed Ig gene rearrangements [12].

Anatomical context of CD37

• Plasma cells showed re-expressed CD9 and downregulated CD37 [13].
• Another two, CD9 and CD37, were detected in 60% of cell lines, and have a very variable level of expression [14].
• Expression of CD37 was not detectable throughout the GI tract [15].
• Previously thought to be predominantly a B cell molecule, CD37 is shown in this study to regulate T cell proliferation [8].
• A regulatory role for CD37 in T cell proliferation [8].

Associations of CD37 with chemical compounds

• Mouse CD37 is a glycoprotein of 281 amino acids in length, encoded by eight exons that span approximately 5.2 kb [16].

Other interactions of CD37

• Participation of other molecules, not examined in this study (CD19 and CD37), in these supramolecular structures cannot be ruled out [17].
• However, these cells expressed neither CD28, a molecule acquired by plasmocytes, nor CD22 and CD37, which are lost during the transition of plasmablasts to plasmocytes [18].
• In the presence of CD28 costimulation, CD37 engagement still significantly reduced proliferation [8].
• In type I cells MHC Class II and the pan B antigens CD19 and CD37 were expressed at levels typical of cells at the B cell stage [19].
• However, CD40 and CD37 were found on the majority of CD34+ cells from either BM or CB, demonstrating that these antigens are not restricted to B-lineage CD34+ cells [20].

References