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Gene Review:

Cd59a - CD59a antigen

Mus musculus

Synonyms: AA987121, CD59A glycoprotein, Cd59, MAC-IP, MAC-inhibitory protein, ...

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Disease relevance of Cd59a

Mice deficient in the Cd59a gene (mCd59a-/-) were used to investigate the role of CD59 in renal ischemia-reperfusion injury [1].
Mice deficient in the Cd59a gene (mCd59a-/-) were used to investigate the role of CD59 in experimentally induced accelerated nephrotoxic nephritis, a model of immune complex-mediated glomerulonephritis [2].

High impact information on Cd59a

To investigate a role for CD59 in promoting T cell responses, we compared T cell activation in CD59a-deficient (Cd59a-/-) and wild-type (WT) mice after in vitro stimulation and after infection with rVV [3].
Analysis of the promoters and 5'-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes [4].
Mice deficient in the C regulators Daf1 and/or Cd59a were tested in the model [5].
Cd59a spans 19 kb, and Cd59b spans 15 kb, with approximately 11.6 kb of genomic DNA separating the two genes [6].
Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b [6].

Biological context of Cd59a

The mouse Cd59 genes encompass a total of 45.6 kb with each gene having four exons [6].
We recently reported that the mouse genome contains two Cd59 genes, while the human and rat genomes each contain only one Cd59 gene (Qian et al. 2000) [6].
Radiation hybrid mapping localised mouse Cd59 between D2Mit333 and D2Mit127 on chromosome 2, a region homologous with human chromosome 11p13 where the human CD59 gene is localised [7].

Anatomical context of Cd59a

Interestingly, testicular Cd59a appeared to be expressed exclusively in spermatids, whereas Cd59b was expressed in more mature sperm cells [6].
Virus-specific CD4+ T cell responses were significantly enhanced in Cd59a-/- mice compared with WT mice [3].
Contrary to our expectations, Cd59a(-/-) mice showed a decreased humoral immune response to a T cell dependent antigen, sheep red blood cells [8].

Analytical, diagnostic and therapeutic context of Cd59a

CNV was induced by laser photocoagulation in C57BL/6 and Cd59a(-/-) mice using an argon laser [9].

References

CD59a deficiency exacerbates ischemia-reperfusion injury in mice. Turnberg, D., Botto, M., Lewis, M., Zhou, W., Sacks, S.H., Morgan, B.P., Walport, M.J., Cook, H.T. Am. J. Pathol. (2004) [Pubmed]
CD59a deficiency exacerbates accelerated nephrotoxic nephritis in mice. Turnberg, D., Botto, M., Warren, J., Morgan, B.P., Walport, M.J., Cook, H.T. J. Am. Soc. Nephrol. (2003) [Pubmed]
Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner. Longhi, M.P., Sivasankar, B., Omidvar, N., Morgan, B.P., Gallimore, A. J. Immunol. (2005) [Pubmed]
Analysis of the promoters and 5'-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes. Qin, X., Ferris, S., Hu, W., Guo, F., Ziegeler, G., Halperin, J.A. Genes Immun. (2006) [Pubmed]
The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice. Morgan, B.P., Chamberlain-Banoub, J., Neal, J.W., Song, W., Mizuno, M., Harris, C.L. Clin. Exp. Immunol. (2006) [Pubmed]
Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b. Qin, X., Miwa, T., Aktas, H., Gao, M., Lee, C., Qian, Y.M., Morton, C.C., Shahsafaei, A., Song, W.C., Halperin, J.A. Mamm. Genome (2001) [Pubmed]
Genomic structure and chromosome location of the gene encoding mouse CD59. Holt, D.S., Powell, M.B., Rushmere, N.K., Morgan, B.P. Cytogenet. Cell Genet. (2000) [Pubmed]
CD59a deficient mice display reduced B cell activity and antibody production in response to T-dependent antigens. Sivasankar, B., Donev, R.M., Longhi, M.P., Hughes, T.R., Davies, R., Cole, D.S., Morgan, B.P., Marchbank, K.J. Mol. Immunol. (2007) [Pubmed]
CD59, a Complement Regulatory Protein, Controls Choroidal Neovascularization in a Mouse Model of Wet-Type Age-Related Macular Degeneration. Bora, N.S., Kaliappan, S., Jha, P., Xu, Q., Sivasankar, B., Harris, C.L., Morgan, B.P., Bora, P.S. J. Immunol. (2007) [Pubmed]

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