Gene Review:
CD59 - CD59 molecule, complement regulatory protein
Homo sapiens
Synonyms:
16.3A5, 1F5, 1F5 antigen, 20 kDa homologous restriction factor, CD59 glycoprotein, ...
- Inherited complete deficiency of 20-kilodalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria. Yamashina, M., Ueda, E., Kinoshita, T., Takami, T., Ojima, A., Ono, H., Tanaka, H., Kondo, N., Orii, T., Okada, N. N. Engl. J. Med. (1990)
- Survival of Helicobacter pylori From complement lysis by binding of GPI-anchored protectin (CD59). Rautemaa, R., Rautelin, H., Puolakkainen, P., Kokkola, A., Kärkkäinen, P., Meri, S. Gastroenterology (2001)
- Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria. Brodsky, R.A., Vala, M.S., Barber, J.P., Medof, M.E., Jones, R.J. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Minor population of CD55-CD59- blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia. Sugimori, C., Chuhjo, T., Feng, X., Yamazaki, H., Takami, A., Teramura, M., Mizoguchi, H., Omine, M., Nakao, S. Blood (2006)
- Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis. Golay, J., Zaffaroni, L., Vaccari, T., Lazzari, M., Borleri, G.M., Bernasconi, S., Tedesco, F., Rambaldi, A., Introna, M. Blood (2000)
- KLF2-dependent, shear stress-induced expression of CD59: a novel cytoprotective mechanism against complement-mediated injury in the vasculature. Kinderlerer, A.R., Ali, F., Johns, M., Lidington, E.A., Leung, V., Boyle, J.J., Hamdulay, S.S., Evans, P.C., Haskard, D.O., Mason, J.C. J. Biol. Chem. (2008)
- Expression of decay-accelerating factor (CD55), membrane cofactor protein (CD46) and CD59 in the human astroglioma cell line, D54-MG, and primary rat astrocytes. Yang, C., Jones, J.L., Barnum, S.R. J. Neuroimmunol. (1993)
- Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria. Miyata, T., Yamada, N., Iida, Y., Nishimura, J., Takeda, J., Kitani, T., Kinoshita, T. N. Engl. J. Med. (1994)
- Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. McCurry, K.R., Kooyman, D.L., Alvarado, C.G., Cotterell, A.H., Martin, M.J., Logan, J.S., Platt, J.L. Nat. Med. (1995)
- Molecular maps of red cell deformation: hidden elasticity and in situ connectivity. Discher, D.E., Mohandas, N., Evans, E.A. Science (1994)
- Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. Hahn, W.C., Menu, E., Bothwell, A.L., Sims, P.J., Bierer, B.E. Science (1992)
- Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts. Nguyen, D.H., Hildreth, J.E. J. Virol. (2000)
- Laboratory diagnosis of paroxysmal nocturnal hemoglobinuria. Krauss, J.S. Ann. Clin. Lab. Sci. (2003)
- Melanoma cells constitutively release an anchor-positive soluble form of protectin (sCD59) that retains functional activities in homologous complement-mediated cytotoxicity. Brasoveanu, L.I., Fonsatti, E., Visintin, A., Pavlovic, M., Cattarossi, I., Colizzi, F., Gasparollo, A., Coral, S., Horejsi, V., Altomonte, M., Maio, M. J. Clin. Invest. (1997)
- Urinary excretion of protectin (CD59), complement SC5b-9 and cytokines in membranous glomerulonephritis. Lehto, T., Honkanen, E., Teppo, A.M., Meri, S. Kidney Int. (1995)
- Identification of differentially expressed genes in cardiac hypertrophy by analysis of expressed sequence tags. Hwang, D.M., Dempsey, A.A., Lee, C.Y., Liew, C.C. Genomics (2000)
- Mutational analysis of the active site and antibody epitopes of the complement-inhibitory glycoprotein, CD59. Bodian, D.L., Davis, S.J., Morgan, B.P., Rushmere, N.K. J. Exp. Med. (1997)
- CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. Davies, A., Simmons, D.L., Hale, G., Harrison, R.A., Tighe, H., Lachmann, P.J., Waldmann, H. J. Exp. Med. (1989)
- Molecular basis for a link between complement and the vascular complications of diabetes. Acosta, J., Hettinga, J., Flückiger, R., Krumrei, N., Goldfine, A., Angarita, L., Halperin, J. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Production and characterization of lymphoblastoid cell lines with the paroxysmal nocturnal hemoglobinuria phenotype. Hillmen, P., Bessler, M., Crawford, D.H., Luzzatto, L. Blood (1993)
- Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity. Omidvar, N., Wang, E.C., Brennan, P., Longhi, M.P., Smith, R.A., Morgan, B.P. J. Immunol. (2006)
- A soluble multimeric recombinant CD2 protein identifies CD48 as a low affinity ligand for human CD2: divergence of CD2 ligands during the evolution of humans and mice. Arulanandam, A.R., Moingeon, P., Concino, M.F., Recny, M.A., Kato, K., Yagita, H., Koyasu, S., Reinherz, E.L. J. Exp. Med. (1993)
- GPI-anchored complement regulatory proteins in seminal plasma. An analysis of their physical condition and the mechanisms of their binding to exogenous cells. Rooney, I.A., Heuser, J.E., Atkinson, J.P. J. Clin. Invest. (1996)
- The glycosylphosphatidylinositol-anchored CD59 protein stimulates both T cell receptor zeta/ZAP-70-dependent and -independent signaling pathways in T cells. Deckert, M., Ticchioni, M., Mari, B., Mary, D., Bernard, A. Eur. J. Immunol. (1995)
- Lipopolysaccharide signal transduction in oral keratinocytes--involvement of CD59 but not CD14. Yamamoto, T., Nakane, T., Doi, S., Osaki, T. Cell. Signal. (2003)
- Detection of a glycosylation-dependent ligand for the T lymphocyte cell adhesion molecule CD2 using a novel multimeric recombinant CD2-binding assay. Parish, C.R., Recny, M.A., Knoppers, M.H., Waldron, J.C., Warren, H.S. J. Immunol. (1993)
- p53 regulates cellular resistance to complement lysis through enhanced expression of CD59. Donev, R.M., Cole, D.S., Sivasankar, B., Hughes, T.R., Morgan, B.P. Cancer Res. (2006)
- Transgenic expression of human complement regulatory proteins in mice results in diminished complement deposition during organ xenoperfusion. McCurry, K.R., Kooyman, D.L., Diamond, L.E., Byrne, G.W., Logan, J.S., Platt, J.L. Transplantation (1995)
- Calreticulin is at the surface of circulating neutrophils and uses CD59 as an adaptor molecule. Ghiran, I., Klickstein, L.B., Nicholson-Weller, A. J. Biol. Chem. (2003)
- CD59 costimulation of T cell activation. CD58 dependence and requirement for glycosylation. Menu, E., Tsai, B.C., Bothwell, A.L., Sims, P.J., Bierer, B.E. J. Immunol. (1994)
- Expression of CD59, a complement regulator protein and a second ligand of the CD2 molecule, and CD46 in normal and neoplastic colorectal epithelium. Koretz, K., Brüderlein, S., Henne, C., Möller, P. Br. J. Cancer (1993)
- Identity of a peptide domain of human C9 that is bound by the cell-surface complement inhibitor, CD59. Chang, C.P., Hüsler, T., Zhao, J., Wiedmer, T., Sims, P.J. J. Biol. Chem. (1994)
- MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells. de Marco, M.C., Martín-Belmonte, F., Kremer, L., Albar, J.P., Correas, I., Vaerman, J.P., Marazuela, M., Byrne, J.A., Alonso, M.A. J. Cell Biol. (2002)
- Expression of complement inhibitors CD46, CD55, and CD59 on tumor cells does not predict clinical outcome after rituximab treatment in follicular non-Hodgkin lymphoma. Weng, W.K., Levy, R. Blood (2001)
- Correction of delF508-CFTR activity with benzo(c)quinolizinium compounds through facilitation of its processing in cystic fibrosis airway cells. Dormer, R.L., Dérand, R., McNeilly, C.M., Mettey, Y., Bulteau-Pignoux, L., Métayé, T., Vierfond, J.M., Gray, M.A., Galietta, L.J., Morris, M.R., Pereira, M.M., Doull, I.J., Becq, F., McPherson, M.A. J. Cell. Sci. (2001)
- The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes. Solomon, K.R., Rudd, C.E., Finberg, R.W. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Human carcinomas variably express the complement inhibitory proteins CD46 (membrane cofactor protein), CD55 (decay-accelerating factor), and CD59 (protectin). Niehans, G.A., Cherwitz, D.L., Staley, N.A., Knapp, D.J., Dalmasso, A.P. Am. J. Pathol. (1996)
- Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation. Tone, M., Walsh, L.A., Waldmann, H. J. Mol. Biol. (1992)