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Gene Review:

hemL - glutamate-1-semialdehyde 2,1-aminomutase

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Elliott, T., Cano, D.A. et al., Elliott, T., Elliott, T. et al.

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Disease relevance of hemL

Mutations in two genes, hemA and hemL, result in auxotrophy for ALA in Salmonella typhimurium, but the roles played by these genes and the mechanism of ALA synthesis are not understood [1].

High impact information on hemL

The lpd, hemL, and aroD mutants had intracellular persistence rates in fibroblasts that were 3 to 4 logs higher than that of the parental strain and decreased susceptibility to aminoglycoside antibiotics [2].
In a strain carrying both a dpp-lac operon fusion and a functional copy of the dpp locus, the expression of beta-galactosidase is not induced by ALA, nor, in a hemL mutant, does expression of dpp change substantially during starvation for ALA [3].
The Hem- phenotype of hemL mutants is less severe than that of hemA mutants [4].

References

Cloning, genetic characterization, and nucleotide sequence of the hemA-prfA operon of Salmonella typhimurium. Elliott, T. J. Bacteriol. (1989) [Pubmed]
Selection of small-colony variants of Salmonella enterica serovar typhimurium in nonphagocytic eucaryotic cells. Cano, D.A., Pucciarelli, M.G., Martínez-Moya, M., Casadesús, J., García-del Portillo, F. Infect. Immun. (2003) [Pubmed]
Transport of 5-aminolevulinic acid by the dipeptide permease in Salmonella typhimurium. Elliott, T. J. Bacteriol. (1993) [Pubmed]
Heme-deficient mutants of Salmonella typhimurium: two genes required for ALA synthesis. Elliott, T., Roth, J.R. Mol. Gen. Genet. (1989) [Pubmed]

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