The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

aroD  -  3-dehydroquinate dehydratase

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of aroD

 

High impact information on aroD

  • The lpd, hemL, and aroD mutants had intracellular persistence rates in fibroblasts that were 3 to 4 logs higher than that of the parental strain and decreased susceptibility to aminoglycoside antibiotics [3].
  • This deletion was introduced by homologous recombination into the chromosomes of two S. typhi strains which already harbored defined deletions in both the aroC and aroD genes [4].
  • In this study, an aroA- and aroD- attenuated strain of Salmonella typhimurium (BRD509) has been used to deliver the recombinant eukaryotic plasmid pSAG(1-2)/CTA2/B expressing a multi-antigenic gene encoding SAG1 and SAG2 of T. gondii linked to A2/B subunits of cholera toxin as a candidate oral T. gondii vaccine [5].
 

Chemical compound and disease context of aroD

  • The gene encoding the Leishmania major (L. major) promastigote surface glycoprotein, gp63, was introduced into the Salmonella typhimurium (S. typhimurium) aroA- aroD- live oral vaccine strain BRD509 and expressed under the control of a constitutive tac promoter in plasmid pKK233-2 [6].

References

  1. Salmonella typhimurium delta aroA delta aroD mutants expressing a foreign recombinant protein induce specific major histocompatibility complex class I-restricted cytotoxic T lymphocytes in mice. Turner, S.J., Carbone, F.R., Strugnell, R.A. Infect. Immun. (1993) [Pubmed]
  2. Characterization of phosphoenolpyruvate synthase mutants in Salmonella typhimurium. Smyer, J.R., Jeter, R.M. Arch. Microbiol. (1989) [Pubmed]
  3. Selection of small-colony variants of Salmonella enterica serovar typhimurium in nonphagocytic eucaryotic cells. Cano, D.A., Pucciarelli, M.G., Martínez-Moya, M., Casadesús, J., García-del Portillo, F. Infect. Immun. (2003) [Pubmed]
  4. Characterization of defined ompR mutants of Salmonella typhi: ompR is involved in the regulation of Vi polysaccharide expression. Pickard, D., Li, J., Roberts, M., Maskell, D., Hone, D., Levine, M., Dougan, G., Chatfield, S. Infect. Immun. (1994) [Pubmed]
  5. Oral immunization with a live recombinant attenuated Salmonella typhimurium protects mice against Toxoplasma gondii. Cong, H., Gu, Q.M., Jiang, Y., He, S.Y., Zhou, H.Y., Yang, T.T., Li, Y., Zhao, Q.L. Parasite Immunol. (2005) [Pubmed]
  6. Protection against Leishmania major infection in genetically susceptible BALB/c mice by gp63 delivered orally in attenuated Salmonella typhimurium (AroA- AroD-). Xu, D., McSorley, S.J., Chatfield, S.N., Dougan, G., Liew, F.Y. Immunology (1995) [Pubmed]
 
WikiGenes - Universities