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Gene Review

aroD  -  3-dehydroquinate dehydratase

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of aroD


High impact information on aroD

  • The lpd, hemL, and aroD mutants had intracellular persistence rates in fibroblasts that were 3 to 4 logs higher than that of the parental strain and decreased susceptibility to aminoglycoside antibiotics [3].
  • This deletion was introduced by homologous recombination into the chromosomes of two S. typhi strains which already harbored defined deletions in both the aroC and aroD genes [4].
  • In this study, an aroA- and aroD- attenuated strain of Salmonella typhimurium (BRD509) has been used to deliver the recombinant eukaryotic plasmid pSAG(1-2)/CTA2/B expressing a multi-antigenic gene encoding SAG1 and SAG2 of T. gondii linked to A2/B subunits of cholera toxin as a candidate oral T. gondii vaccine [5].

Chemical compound and disease context of aroD

  • The gene encoding the Leishmania major (L. major) promastigote surface glycoprotein, gp63, was introduced into the Salmonella typhimurium (S. typhimurium) aroA- aroD- live oral vaccine strain BRD509 and expressed under the control of a constitutive tac promoter in plasmid pKK233-2 [6].


  1. Salmonella typhimurium delta aroA delta aroD mutants expressing a foreign recombinant protein induce specific major histocompatibility complex class I-restricted cytotoxic T lymphocytes in mice. Turner, S.J., Carbone, F.R., Strugnell, R.A. Infect. Immun. (1993) [Pubmed]
  2. Characterization of phosphoenolpyruvate synthase mutants in Salmonella typhimurium. Smyer, J.R., Jeter, R.M. Arch. Microbiol. (1989) [Pubmed]
  3. Selection of small-colony variants of Salmonella enterica serovar typhimurium in nonphagocytic eucaryotic cells. Cano, D.A., Pucciarelli, M.G., Martínez-Moya, M., Casadesús, J., García-del Portillo, F. Infect. Immun. (2003) [Pubmed]
  4. Characterization of defined ompR mutants of Salmonella typhi: ompR is involved in the regulation of Vi polysaccharide expression. Pickard, D., Li, J., Roberts, M., Maskell, D., Hone, D., Levine, M., Dougan, G., Chatfield, S. Infect. Immun. (1994) [Pubmed]
  5. Oral immunization with a live recombinant attenuated Salmonella typhimurium protects mice against Toxoplasma gondii. Cong, H., Gu, Q.M., Jiang, Y., He, S.Y., Zhou, H.Y., Yang, T.T., Li, Y., Zhao, Q.L. Parasite Immunol. (2005) [Pubmed]
  6. Protection against Leishmania major infection in genetically susceptible BALB/c mice by gp63 delivered orally in attenuated Salmonella typhimurium (AroA- AroD-). Xu, D., McSorley, S.J., Chatfield, S.N., Dougan, G., Liew, F.Y. Immunology (1995) [Pubmed]
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