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MeSH Review

Pigment Epithelium of Eye

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Disease relevance of Pigment Epithelium of Eye


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Chemical compound and disease context of Pigment Epithelium of Eye


Biological context of Pigment Epithelium of Eye


Anatomical context of Pigment Epithelium of Eye


Associations of Pigment Epithelium of Eye with chemical compounds


Gene context of Pigment Epithelium of Eye


Analytical, diagnostic and therapeutic context of Pigment Epithelium of Eye


  1. Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome. Bassi, M.T., Schiaffino, M.V., Renieri, A., De Nigris, F., Galli, L., Bruttini, M., Gebbia, M., Bergen, A.A., Lewis, R.A., Ballabio, A. Nat. Genet. (1995) [Pubmed]
  2. Altered aldose reductase gene regulation in cultured human retinal pigment epithelial cells. Henry, D.N., Del Monte, M., Greene, D.A., Killen, P.D. J. Clin. Invest. (1993) [Pubmed]
  3. Congenital hypertrophy of retinal pigment epithelium and risk estimation in adenomatous polyposis coli. Maher, E.R., Moore, A.T. Lancet (1990) [Pubmed]
  4. Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Van Hooser, J.P., Aleman, T.S., He, Y.G., Cideciyan, A.V., Kuksa, V., Pittler, S.J., Stone, E.M., Jacobson, S.G., Palczewski, K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. Mutations in a novel gene, VMD2, encoding a protein of unknown properties cause juvenile-onset vitelliform macular dystrophy (Best's disease). Marquardt, A., Stöhr, H., Passmore, L.A., Krämer, F., Rivera, A., Weber, B.H. Hum. Mol. Genet. (1998) [Pubmed]
  6. A syndrome of multiple fundal anomalies in siblings with microcephaly without mental retardation. Sheriff, S.M., Hegab, S. Ophthalmic surgery. (1988) [Pubmed]
  7. Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. Jin, M., Li, S., Moghrabi, W.N., Sun, H., Travis, G.H. Cell (2005) [Pubmed]
  8. New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis. Seeliger, M.W., Grimm, C., Ståhlberg, F., Friedburg, C., Jaissle, G., Zrenner, E., Guo, H., Remé, C.E., Humphries, P., Hofmann, F., Biel, M., Fariss, R.N., Redmond, T.M., Wenzel, A. Nat. Genet. (2001) [Pubmed]
  9. Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin. Sprecher, E., Bergman, R., Richard, G., Lurie, R., Shalev, S., Petronius, D., Shalata, A., Anbinder, Y., Leibu, R., Perlman, I., Cohen, N., Szargel, R. Nat. Genet. (2001) [Pubmed]
  10. A photic visual cycle of rhodopsin regeneration is dependent on Rgr. Chen, P., Hao, W., Rife, L., Wang, X.P., Shen, D., Chen, J., Ogden, T., Van Boemel, G.B., Wu, L., Yang, M., Fong, H.K. Nat. Genet. (2001) [Pubmed]
  11. Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus. Yamamoto, H., Simon, A., Eriksson, U., Harris, E., Berson, E.L., Dryja, T.P. Nat. Genet. (1999) [Pubmed]
  12. Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus. Jang, G.F., Van Hooser, J.P., Kuksa, V., McBee, J.K., He, Y.G., Janssen, J.J., Driessen, C.A., Palczewski, K. J. Biol. Chem. (2001) [Pubmed]
  13. Deferoxamine (Desferal)-induced toxic retinal pigmentary degeneration and presumed optic neuropathy. Lakhanpal, V., Schocket, S.S., Jiji, R. Ophthalmology (1984) [Pubmed]
  14. Vitamin A-responsive panocular xerophthalmia in a healthy adult. Sommer, A., Tjakrasudjatma, S., Djunaedi, E., Green, W.R. Arch. Ophthalmol. (1978) [Pubmed]
  15. Phagocytic activity of cultured retinal pigment epithelium. Uptake of polystyrene spheres and Staphylococcus aureus. Hayashi, M., Matsumoto, A., Hamashima, Y., Tsukahara, I. Exp. Eye Res. (1979) [Pubmed]
  16. Effect of phytanic acid on cultured retinal pigment epithelium: an in vitro model for Refsum's disease. Bernstein, P.S., Lloyd, M.B., O'Day, W.T., Bok, D. Exp. Eye Res. (1992) [Pubmed]
  17. Identification of a membrane protein binding the retinol in retinal pigment epithelium. Maraini, G., Ottonello, S., Gozzoli, F., Merli, A. Nature (1977) [Pubmed]
  18. Retinal network adaptation to bright light requires tyrosinase. Page-McCaw, P.S., Chung, S.C., Muto, A., Roeser, T., Staub, W., Finger-Baier, K.C., Korenbrot, J.I., Baier, H. Nat. Neurosci. (2004) [Pubmed]
  19. Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors. Finnemann, S.C. EMBO J. (2003) [Pubmed]
  20. Growth factors regulate phototransduction in retinal rods by modulating cyclic nucleotide-gated channels through dephosphorylation of a specific tyrosine residue. Savchenko, A., Kraft, T.W., Molokanova, E., Kramer, R.H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  21. Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus. Flannery, J.G., Zolotukhin, S., Vaquero, M.I., LaVail, M.M., Muzyczka, N., Hauswirth, W.W. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  22. Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa. Maw, M.A., Kennedy, B., Knight, A., Bridges, R., Roth, K.E., Mani, E.J., Mukkadan, J.K., Nancarrow, D., Crabb, J.W., Denton, M.J. Nat. Genet. (1997) [Pubmed]
  23. Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium. Marmorstein, A.D., Marmorstein, L.Y., Rayborn, M., Wang, X., Hollyfield, J.G., Petrukhin, K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  24. Carbonic anhydrase XIV is enriched in specific membrane domains of retinal pigment epithelium, Muller cells, and astrocytes. Nagelhus, E.A., Mathiisen, T.M., Bateman, A.C., Haug, F.M., Ottersen, O.P., Grubb, J.H., Waheed, A., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  25. Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells. Chen, F., Figueroa, D.J., Marmorstein, A.D., Zhang, Q., Petrukhin, K., Caskey, C.T., Austin, C.P. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  26. Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Hahn, P., Qian, Y., Dentchev, T., Chen, L., Beard, J., Harris, Z.L., Dunaief, J.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  27. Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Redmond, T.M., Yu, S., Lee, E., Bok, D., Hamasaki, D., Chen, N., Goletz, P., Ma, J.X., Crouch, R.K., Pfeifer, K. Nat. Genet. (1998) [Pubmed]
  28. Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration. Grimm, C., Wenzel, A., Hafezi, F., Yu, S., Redmond, T.M., Remé, C.E. Nat. Genet. (2000) [Pubmed]
  29. Treatment with aldose reductase inhibitor or with myo-inositol arrests deterioration of the electroretinogram of diabetic rats. MacGregor, L.C., Matschinsky, F.M. J. Clin. Invest. (1985) [Pubmed]
  30. Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia. Deora, A.A., Philp, N., Hu, J., Bok, D., Rodriguez-Boulan, E. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  31. RPE65 is the isomerohydrolase in the retinoid visual cycle. Moiseyev, G., Chen, Y., Takahashi, Y., Wu, B.X., Ma, J.X. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  32. Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E. Kim, S.R., Fishkin, N., Kong, J., Nakanishi, K., Allikmets, R., Sparrow, J.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  33. Leber congenital amaurosis and retinitis pigmentosa with Coats-like exudative vasculopathy are associated with mutations in the crumbs homologue 1 (CRB1) gene. den Hollander, A.I., Heckenlively, J.R., van den Born, L.I., de Kok, Y.J., van der Velde-Visser, S.D., Kellner, U., Jurklies, B., van Schooneveld, M.J., Blankenagel, A., Rohrschneider, K., Wissinger, B., Cruysberg, J.R., Deutman, A.F., Brunner, H.G., Apfelstedt-Sylla, E., Hoyng, C.B., Cremers, F.P. Am. J. Hum. Genet. (2001) [Pubmed]
  34. Identification of the endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium. Saari, J.C., Bredberg, L., Garwin, G.G. J. Biol. Chem. (1982) [Pubmed]
  35. Inflammatory mediators in uveitis: differential induction of cytokines and chemokines in Th1- versus Th2-mediated ocular inflammation. Foxman, E.F., Zhang, M., Hurst, S.D., Muchamuel, T., Shen, D., Wawrousek, E.F., Chan, C.C., Gery, I. J. Immunol. (2002) [Pubmed]
  36. Chick embryonic pigmented retina is one of the group of epithelioid tissues that lack cytokeratins and desmosomes and have intermediate filaments composed of vimentin. Docherty, R.J., Edwards, J.G., Garrod, D.R., Mattey, D.L. J. Cell. Sci. (1984) [Pubmed]
  37. Alpha-1-adrenergic modulation of K and Cl transport in bovine retinal pigment epithelium. Joseph, D.P., Miller, S.S. J. Gen. Physiol. (1992) [Pubmed]
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