Gene Review:
Kcnq1 - potassium voltage-gated channel, subfamily...
Mus musculus
Synonyms:
AW559127, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, KVLQT1, Kcna9, ...
- Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human. Yatsuki, H., Watanabe, H., Hattori, M., Joh, K., Soejima, H., Komoda, H., Xin, Z., Zhu, X., Higashimoto, K., Nishimura, M., Kuratomi, S., Sasaki, H., Sakaki, Y., Mukai, T. DNA Res. (2000)
- Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange-Nielsen Syndrome. Casimiro, M.C., Knollmann, B.C., Ebert, S.N., Vary, J.C., Greene, A.E., Franz, M.R., Grinberg, A., Huang, S.P., Pfeifer, K. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Heightened susceptibility to chronic gastritis, hyperplasia and metaplasia in Kcnq1 mutant mice. Elso, C.M., Lu, X., Culiat, C.T., Rutledge, J.C., Cacheiro, N.L., Generoso, W.M., Stubbs, L.J. Hum. Mol. Genet. (2004)
- Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Umlauf, D., Goto, Y., Cao, R., Cerqueira, F., Wagschal, A., Zhang, Y., Feil, R. Nat. Genet. (2004)
- Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes. Mancini-Dinardo, D., Steele, S.J., Levorse, J.M., Ingram, R.S., Tilghman, S.M. Genes Dev. (2006)
- Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. Lee, M.P., Ravenel, J.D., Hu, R.J., Lustig, L.R., Tomaselli, G., Berger, R.D., Brandenburg, S.A., Litzi, T.J., Bunton, T.E., Limb, C., Francis, H., Gorelikow, M., Gu, H., Washington, K., Argani, P., Goldenring, J.R., Coffey, R.J., Feinberg, A.P. J. Clin. Invest. (2000)
- NF-Y regulates the antisense promoter, bidirectional silencing, and differential epigenetic marks of the Kcnq1 imprinting control region. Pandey, R.R., Ceribelli, M., Singh, P.B., Ericsson, J., Mantovani, R., Kanduri, C. J. Biol. Chem. (2004)
- Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family. Enklaar, T., Esswein, M., Oswald, M., Hilbert, K., Winterpacht, A., Higgins, M., Zabel, B., Prawitt, D. Genomics (2000)
- An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region. Thakur, N., Tiwari, V.K., Thomassin, H., Pandey, R.R., Kanduri, M., Göndör, A., Grange, T., Ohlsson, R., Kanduri, C. Mol. Cell. Biol. (2004)
- Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo. Lewis, A., Green, K., Dawson, C., Redrup, L., Huynh, K.D., Lee, J.T., Hemberger, M., Reik, W. Development (2006)
- Targeted point mutagenesis of mouse Kcnq1: phenotypic analysis of mice with point mutations that cause Romano-Ward syndrome in humans. Casimiro, M.C., Knollmann, B.C., Yamoah, E.N., Nie, L., Vary, J.C., Sirenko, S.G., Greene, A.E., Grinberg, A., Huang, S.P., Ebert, S.N., Pfeifer, K. Genomics (2004)
- Protein distribution of Kcnq1, Kcnh2, and Kcne3 potassium channel subunits during mouse embryonic development. de Castro, M.P., Aránega, A., Franco, D. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2006)
- Inner ear abnormalities in a Kcnq1 (Kvlqt1) knockout mouse: a model of Jervell and Lange-Nielsen syndrome. Rivas, A., Francis, H.W. Otol. Neurotol. (2005)
- Imprinting of mouse Kvlqt1 is developmentally regulated. Gould, T.D., Pfeifer, K. Hum. Mol. Genet. (1998)
- Strain-dependent developmental relaxation of imprinting of an endogenous mouse gene, Kvlqt1. Jiang, S., Hemann, M.A., Lee, M.P., Feinberg, A.P. Genomics (1998)
- Nicotine induces a long QT phenotype in Kcnq1-deficient mouse hearts. Tosaka, T., Casimiro, M.C., Rong, Q., Tella, S., Oh, M., Katchman, A.N., Pezzullo, J.C., Pfeifer, K., Ebert, S.N. J. Pharmacol. Exp. Ther. (2003)
- Increased plasticity of genomic imprinting of Dlk1 in brain is due to genetic and epigenetic factors. Croteau, S., Roquis, D., Charron, M.C., Frappier, D., Yavin, D., Loredo-Osti, J.C., Hudson, T.J., Naumova, A.K. Mamm. Genome (2005)
- A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencer. Mancini-DiNardo, D., Steele, S.J., Ingram, R.S., Tilghman, S.M. Hum. Mol. Genet. (2003)