Disease relevance of Cdc37

• Although targeted overexpression in mice leads to prostate epithelial cell hyperplasia, the effect of Cdc37 dysregulation in human prostate cells is unclear [1].
• Cdc37 up-regulation is a common early event in localized human prostate cancer [1].

High impact information on Cdc37

• Cdc37 is coexpressed with cyclin Dl in cells undergoing programmed proliferation in vivo, consistent with a positive role in cell cycle progression [2].
• We demonstrate that Cdc37 overexpression drives proliferation, whereas loss of Cdc37 function arrests growth and leads to apoptosis [1].
• The interaction between mouse Pem and Cdc37 homolog was then confirmed by glutathione S-transferase pull-down assay, and the possible interaction model was suggested [3].
• Seven individual insert fragments were obtained from the library, and three of them were identified, one of which was confirmed to be the cell division cycle 37 (Cdc37) homolog gene by sequencing [3].

Anatomical context of Cdc37

• In this study, we examine the role of Cdc37 in the growth regulation of normal prostate epithelial cells using a unique human model system [1].

References