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Gene Review

Cdc37  -  cell division cycle 37

Mus musculus

Synonyms: Hsp90 chaperone protein kinase-targeting subunit, Hsp90 co-chaperone Cdc37, p50, p50Cdc37
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Disease relevance of Cdc37


High impact information on Cdc37

  • Cdc37 is coexpressed with cyclin Dl in cells undergoing programmed proliferation in vivo, consistent with a positive role in cell cycle progression [2].
  • We demonstrate that Cdc37 overexpression drives proliferation, whereas loss of Cdc37 function arrests growth and leads to apoptosis [1].
  • The interaction between mouse Pem and Cdc37 homolog was then confirmed by glutathione S-transferase pull-down assay, and the possible interaction model was suggested [3].
  • Seven individual insert fragments were obtained from the library, and three of them were identified, one of which was confirmed to be the cell division cycle 37 (Cdc37) homolog gene by sequencing [3].

Anatomical context of Cdc37

  • In this study, we examine the role of Cdc37 in the growth regulation of normal prostate epithelial cells using a unique human model system [1].


  1. Cdc37 enhances proliferation and is necessary for normal human prostate epithelial cell survival. Schwarze, S.R., Fu, V.X., Jarrard, D.F. Cancer Res. (2003) [Pubmed]
  2. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Stepanova, L., Leng, X., Parker, S.B., Harper, J.W. Genes Dev. (1996) [Pubmed]
  3. Interaction of mouse Pem protein and cell division cycle 37 homolog. Guo, F., Li, Y.Q., Li, S.Q., Luo, Z.W., Zhang, X., Tang, D.S., Zhou, T.H. Acta Biochim. Biophys. Sin. (Shanghai) (2005) [Pubmed]
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