Gene Review:
CDC37 - cell division cycle 37
Homo sapiens
Synonyms:
CDC37A, Hsp90 chaperone protein kinase-targeting subunit, Hsp90 co-chaperone Cdc37, P50CDC37, p50Cdc37
- Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer. Pascale, R.M., Simile, M.M., Calvisi, D.F., Frau, M., Muroni, M.R., Seddaiu, M.A., Daino, L., Muntoni, M.D., De Miglio, M.R., Thorgeirsson, S.S., Feo, F. Hepatology (2005)
- Role of p50/CDC37 in hepadnavirus assembly and replication. Wang, X., Grammatikakis, N., Hu, J. J. Biol. Chem. (2002)
- Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia. Stepanova, L., Yang, G., DeMayo, F., Wheeler, T.M., Finegold, M., Thompson, T.C., Harper, J.W. Oncogene (2000)
- Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37. Nony, P., Gaude, H., Rossel, M., Fournier, L., Rouault, J.P., Billaud, M. Oncogene (2003)
- The Platelet-derived Growth Factor Receptor {alpha} Is Destabilized by Geldanamycins in Cancer Cells. Matei, D., Satpathy, M., Cao, L., Lai, Y.C., Nakshatri, H., Donner, D.B. J. Biol. Chem. (2007)
- A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Tzivion, G., Luo, Z., Avruch, J. Nature (1998)
- Structure of an Hsp90-Cdc37-Cdk4 complex. Vaughan, C.K., Gohlke, U., Sobott, F., Good, V.M., Ali, M.M., Prodromou, C., Robinson, C.V., Saibil, H.R., Pearl, L.H. Mol. Cell (2006)
- TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Chen, G., Cao, P., Goeddel, D.V. Mol. Cell (2002)
- Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation. Mandal, A.K., Lee, P., Chen, J.A., Nillegoda, N., Heller, A., Distasio, S., Oen, H., Victor, J., Nair, D.M., Brodsky, J.L., Caplan, A.J. J. Cell Biol. (2007)
- Identification of a conserved sequence motif that promotes Cdc37 and cyclin D1 binding to Cdk4. Zhao, Q., Boschelli, F., Caplan, A.J., Arndt, K.T. J. Biol. Chem. (2004)
- A client-binding site of Cdc37. Terasawa, K., Minami, Y. FEBS J. (2005)
- Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37. Shao, J., Prince, T., Hartson, S.D., Matts, R.L. J. Biol. Chem. (2003)
- Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. Lavictoire, S.J., Parolin, D.A., Klimowicz, A.C., Kelly, J.F., Lorimer, I.A. J. Biol. Chem. (2003)
- Rapid activation of c-Src kinase by dioxin is mediated by the Cdc37-HSP90 complex as part of Ah receptor signaling in MCF10A cells. Park, S., Dong, B., Matsumura, F. Biochemistry (2007)
- Direct interaction of the cell division cycle 37 homolog inhibits endothelial nitric oxide synthase activity. Harris, M.B., Bartoli, M., Sood, S.G., Matts, R.L., Venema, R.C. Circ. Res. (2006)
- Cdk2: a genuine protein kinase client of Hsp90 and Cdc37. Prince, T., Sun, L., Matts, R.L. Biochemistry (2005)
- Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases. Terasawa, K., Yoshimatsu, K., Iemura, S., Natsume, T., Tanaka, K., Minami, Y. Mol. Cell. Biol. (2006)
- Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37. Prince, T., Matts, R.L. J. Biol. Chem. (2004)
- 1H, 13C and 15N backbone resonance assignment of the Hsp90 binding domain of human Cdc37. Sreeramulu, S., Kumar, J., Richter, C., Vogtherr, M., Saxena, K., Langer, T., Schwalbe, H. J. Biomol. NMR (2005)
- Functional dissection of cdc37: characterization of domain structure and amino acid residues critical for protein kinase binding. Shao, J., Irwin, A., Hartson, S.D., Matts, R.L. Biochemistry (2003)
- Domain-mediated dimerization of the Hsp90 cochaperones Harc and Cdc37. Roiniotis, J., Masendycz, P., Ho, S., Scholz, G.M. Biochemistry (2005)
- High affinity binding of Hsp90 is triggered by multiple discrete segments of its kinase clients. Scroggins, B.T., Prince, T., Shao, J., Uma, S., Huang, W., Guo, Y., Yun, B.G., Hedman, K., Matts, R.L., Hartson, S.D. Biochemistry (2003)
- Cyclin D1 overexpression is not a specific grouping marker, but may collaborate with CDC37 in myeloma cells. Katayama, Y., Sakai, A., Okikawa, Y., Oue, N., Asaoku, H., Sasaki, A., Imanaka, F., Tsujimoto, T., Takimoto, Y., Masuda, R., Nakaju, N., Otsuki, T., Yasui, W., Kimura, A. Int. J. Oncol. (2004)