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Gene Review:

Cdc37 - CG12019 gene product from transcript...

Drosophila melanogaster

Synonyms: CG12019, CPDR-1, CPDR-2, DROCPDR, Dmel\CG12019, ...

Lange, B.M. et al., Cutforth, T. et al., Kimura, Y. et al.

Lange, Rebollo, Herold, González,

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High impact information on Cdc37

Mutations in E(sev)3B also dominantly enhance mutations in Dmcdc2, the gene encoding the p34 protein kinase that regulates the G2/M transition [1].
Cdc37 is a molecular chaperone with specific functions in signal transduction [2].
Here we show that the loss of function of Cdc37 in Drosophila leads to defects in mitosis and male meiosis, and that these phenotypes closely resemble those brought about by the inactivation of Aurora B [3].
These observations substantiate the role of Cdc37 as an upstream regulatory element of key cell cycle kinases [3].
Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes [3].

Biological context of Cdc37

However, little is known so far regarding interactions of Cdc37 with kinases that play a role in cell division [3].

References

Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila. Cutforth, T., Rubin, G.M. Cell (1994) [Pubmed]
Cdc37 is a molecular chaperone with specific functions in signal transduction. Kimura, Y., Rutherford, S.L., Miyata, Y., Yahara, I., Freeman, B.C., Yue, L., Morimoto, R.I., Lindquist, S. Genes Dev. (1997) [Pubmed]
Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes. Lange, B.M., Rebollo, E., Herold, A., González, C. EMBO J. (2002) [Pubmed]

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