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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

aroC  -  chorismate synthase

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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Disease relevance of aroC

  • A live attenuated Salmonella typhimurium vaccine candidate, LVR01, was constructed by introducing a null deletion into the aroC gene of the parental canine S. typhimurium isolate, P228067 [1].
 

High impact information on aroC

  • Typhimurium aroC in delivering a eukaryotic promoter-driven green fluorescent protein reporter gene for expression in dendritic cells [2].
  • This deletion was introduced by homologous recombination into the chromosomes of two S. typhi strains which already harbored defined deletions in both the aroC and aroD genes [3].
  • The aroC locus is found within the duplicated region, and aroC321/aroC321 merodiploids apparently grow as tryptophan prototrophs because of a gene-dosage effect [4].
  • We tested two new strains of Salmonella typhimurium, one carrying a mutation in a SPI-2 gene and the aroC-gene and another carrying mutations in the sifA- and aroC-genes, as potential DNA vaccine delivery vehicles [5].

References

  1. Salmonella typhimurium as a basis for a live oral Echinococcus granulosus vaccine. Chabalgoity, J.A., Moreno, M., Carol, H., Dougan, G., Hormaeche, C.E. Vaccine (2000) [Pubmed]
  2. Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene. Petrovska, L., Aspinall, R.J., Barber, L., Clare, S., Simmons, C.P., Stratford, R., Khan, S.A., Lemoine, N.R., Frankel, G., Holden, D.W., Dougan, G. Cell. Microbiol. (2004) [Pubmed]
  3. Characterization of defined ompR mutants of Salmonella typhi: ompR is involved in the regulation of Vi polysaccharide expression. Pickard, D., Li, J., Roberts, M., Maskell, D., Hone, D., Levine, M., Dougan, G., Chatfield, S. Infect. Immun. (1994) [Pubmed]
  4. Genetic instability associated with the aroC321 allele in Salmonella typhimurium involves genetic duplication. Hoffman, G.R., Walkowicz, M.J., Mason, J.M., Atkins, J.F. Mol. Gen. Genet. (1983) [Pubmed]
  5. Novel strains of Salmonella typhimurium as potential vectors for gene delivery. Michael, A., Stratford, R., Khan, S., Dalgleish, A., Pandha, H. FEMS Microbiol. Lett. (2004) [Pubmed]
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