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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

orgA  -  oxygen-regulated invasion protein OrgA

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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Disease relevance of orgA

  • We have compared the virulence of S. typhimurium SL1344 and an isogenic orgA mutant in a mouse model of typhoid fever [1].
  • The orgA gene from Salmonella enterica serovar Typhimurium is involved in promoting cellular invasion of the pathogen [2].
 

High impact information on orgA

  • Here, we present experiments indicating that orgA expression is driven by the prgH promoter [3].
  • These genes have been designated orgA and orgB [3].
  • We report that an error in the published orgA DNA sequence has been identified so that this region encodes two small genes rather than a single large open reading frame [3].
  • A 1.9-kb EcoRV DNA fragment subcloned from this cosmid, containing a single open reading frame (orgA), restores the ability of BJ66 to invade mammalian cells [1].
  • Six class 1 and six class 2 mutants have insertions in SPI-1 near the invasion gene orgA or the invasion gene regulator hilD, respectively [4].
 

Analytical, diagnostic and therapeutic context of orgA

  • In this study a novel competitive RT-PCR (cRT-PCR) system was developed to measure the steady-state orgA specific mRNA levels in cells under various growth parameters [2].

References

  1. Identification and characterization of a Salmonella typhimurium oxygen-regulated gene required for bacterial internalization. Jones, B.D., Falkow, S. Infect. Immun. (1994) [Pubmed]
  2. The steady-state orgA specific mRNA levels in Salmonella enterica serovar Typhimurium are repressed by oxygen during logarithmic growth phase but not early-stationary phase. Russell, D.A., Dooley, J.S., Haylock, R.W. FEMS Microbiol. Lett. (2004) [Pubmed]
  3. Transcriptional organization and function of invasion genes within Salmonella enterica serovar Typhimurium pathogenicity island 1, including the prgH, prgI, prgJ, prgK, orgA, orgB, and orgC genes. Klein, J.R., Fahlen, T.F., Jones, B.D. Infect. Immun. (2000) [Pubmed]
  4. Identification and characterization of mutants with increased expression of hilA, the invasion gene transcriptional activator of Salmonella typhimurium. Fahlen, T.F., Mathur, N., Jones, B.D. FEMS Immunol. Med. Microbiol. (2000) [Pubmed]
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