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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

orgA  -  oxygen-regulated invasion protein OrgA

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of orgA

  • We have compared the virulence of S. typhimurium SL1344 and an isogenic orgA mutant in a mouse model of typhoid fever [1].
  • The orgA gene from Salmonella enterica serovar Typhimurium is involved in promoting cellular invasion of the pathogen [2].

High impact information on orgA

  • Here, we present experiments indicating that orgA expression is driven by the prgH promoter [3].
  • These genes have been designated orgA and orgB [3].
  • We report that an error in the published orgA DNA sequence has been identified so that this region encodes two small genes rather than a single large open reading frame [3].
  • A 1.9-kb EcoRV DNA fragment subcloned from this cosmid, containing a single open reading frame (orgA), restores the ability of BJ66 to invade mammalian cells [1].
  • Six class 1 and six class 2 mutants have insertions in SPI-1 near the invasion gene orgA or the invasion gene regulator hilD, respectively [4].

Analytical, diagnostic and therapeutic context of orgA

  • In this study a novel competitive RT-PCR (cRT-PCR) system was developed to measure the steady-state orgA specific mRNA levels in cells under various growth parameters [2].


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