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Gene Review:

tuf - elongation factor Tu

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Arwidsson, O. et al., Aulin, M.R. et al.

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Disease relevance of tuf

Evidence against reciprocal recombination as the basis for tuf gene conversion in Salmonella enterica serovar Typhimurium [1].

High impact information on tuf

We conclude that the evidence argues in favor of a non-reciprocal gene conversion mechanism as the basis for tuf gene co-evolution [1].
However, in a replicating bacterial chromosome there is a possibility that a reciprocal genetic exchange between different tuf genes sitting on sister chromosomes could result in "apparent" gene conversion [1].
We introduced plasmids synthesizing either one of the release factors into strains in which the tuf mutations suppress a test frameshift mutation [2].

References

Evidence against reciprocal recombination as the basis for tuf gene conversion in Salmonella enterica serovar Typhimurium. Arwidsson, O., Hughes, D. J. Mol. Biol. (2004) [Pubmed]
Overproduction of release factor reduces spontaneous frameshifting and frameshift suppression by mutant elongation factor Tu. Aulin, M.R., Hughes, D. J. Bacteriol. (1990) [Pubmed]

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