Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ggt - gamma-glutamyltranspeptidase

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Stark, A.A. et al., Stark, A.A. et al., Sinués, B. et al., Chen, R.M. et al.

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Disease relevance of ggt

Reduced glutathione (GSH) is mutagenic in Salmonella in the presence of gamma-glutamyltranspeptidase (GGT), with the highest response obtained in strain TA102 [1].

High impact information on ggt

Glutathione mutagenesis in Salmonella typhimurium is a gamma-glutamyltranspeptidase-enhanced process involving active oxygen species [1].
Even though folic acid and gamma-glutamyltranspeptidase were significantly different in patients and controls, there was no significant association between these values and SCE or PRI [2].
Pretreatment with 6-NC elevated serum gamma-glutamyltranspeptidase, lactate dehydrogenase, and bilirubin levels [3].

Associations of ggt with chemical compounds

Glutathione-mediated, gamma-glutamyltranspeptidase-dependent mutagenesis of TA100 cells was inhibited by serine-borate complex, a known gamma-glutamyltranspeptidase inhibitor, and potentiated by glycylglycine, a known gamma-glutamyltranspeptidase enhancer [4].

References

Glutathione mutagenesis in Salmonella typhimurium is a gamma-glutamyltranspeptidase-enhanced process involving active oxygen species. Stark, A.A., Zeiger, E., Pagano, D.A. Carcinogenesis (1988) [Pubmed]
Six mutagenicity assays in exposure biomonitoring of patients receiving carbamazepine for epilepsy or trigeminal neuralgia. Sinués, B., Gazulla, J., Bernal, M.L., Lanuza, J., Fanlo, A., Saenz, M.A., Barolome, M. Mutat. Res. (1995) [Pubmed]
Induction of cytochrome P450 1A in hamster liver and lung by 6-nitrochrysene. Chen, R.M., Chou, M.W., Ueng, T.H. Arch. Toxicol. (1998) [Pubmed]
Glutathione mutagenesis in Salmonella typhimurium TA100: dependence on a single enzyme, gamma-glutamyltranspeptidase. Stark, A.A., Zeiger, E., Pagano, D.A. Mutat. Res. (1987) [Pubmed]

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