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Chemical Compound Review

Serine-borate     (2S)-2-amino-3-hydroxy- propanoic acid;...

Synonyms: AC1L56SZ, 51839-17-9, L-Serine, mixt. with boric acid (H3BO3)
 
 
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Disease relevance of Serine-borate

  • The extents of peptidolysis of [3]LTC4 and [3]LTD4 by 100 microliter of pulmonary edema fluid attained respective mean maximum levels of 74.5 +/- 2.9% (N = 5) and 37.7 +/- 10.2% (N = 4) after 30 min at 37 degrees C and were inhibited by serine-borate and by cysteine, respectively [1].
 

High impact information on Serine-borate

 

Biological context of Serine-borate

 

Anatomical context of Serine-borate

 

Associations of Serine-borate with other chemical compounds

  • Caput luminal GGT transpeptidation activity was significantly inhibited by serine-borate and was optimal at pH 8 [15].
  • Serine-borate, a competitive inhibitor of GGT, blocked the restoration of intracellular glutathione [16].
  • We found that y-glutamyl transpeptidase activity induces NF-kappaB DNA binding activity, an effect which is significantly reduced by the addition of GGT inhibitors (Serine/Borate complex and Acivicin) [8].
  • LTC4 formation, measured in vitro, was linear for > 10 min at 25 degrees C in the presence of 50 mM serine borate (an inhibitor of gamma-glutamyl transpeptidase), with Km values for LTA4 and GSH of 56 microM and 8.5 mM, respectively [17].
 

Gene context of Serine-borate

 

Analytical, diagnostic and therapeutic context of Serine-borate

  • Over 94% of plasma-derived GSH remained in its original molecular form of GSH in the lens, during the 10 min perfusion both with and without the GGT inhibitor, serine borate [19].

References

  1. Sulfidopeptide-leukotriene peptidases in pulmonary edema fluid from patients with the adult respiratory distress syndrome. Ratnoff, W.D., Matthay, M.A., Wong, M.Y., Ito, Y., Vu, K.H., Wiener-Kronish, J., Goetzl, E.J. J. Clin. Immunol. (1988) [Pubmed]
  2. Serine-borate complex as a transition-state inhibitor of gamma-glutamyl transpeptidase. Tate, S.S., Meister, A. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  3. Alteration in gamma-glutamyl transpeptidase activity and messenger RNA of human prostate carcinoma cells by androgen. Ripple, M.O., Pickhardt, P.A., Wilding, G. Cancer Res. (1997) [Pubmed]
  4. Gamma-glutamyl transpeptidase-mediated transport of amino acid in lecithin vesicles. Sikka, S.C., Kalra, V.K. J. Biol. Chem. (1980) [Pubmed]
  5. Characteristics of large neutral amino acid-induced release of preloaded L-glutamine from rat cerebral capillaries in vitro: effects of ammonia, hepatic encephalopathy, and gamma-glutamyl transpeptidase inhibitors. Hilgier, W., Puka, M., Albrecht, J. J. Neurosci. Res. (1992) [Pubmed]
  6. Effect of specific inhibition of gamma-glutamyl transpeptidase on amino acid uptake by mammary gland of the lactating rat. Viña, J., Puertes, I.R., Montoro, J.B., Viña, J.R. FEBS Lett. (1983) [Pubmed]
  7. Glutathione mutagenesis in Salmonella typhimurium TA100: dependence on a single enzyme, gamma-glutamyltranspeptidase. Stark, A.A., Zeiger, E., Pagano, D.A. Mutat. Res. (1987) [Pubmed]
  8. Gamma-glutamyl transpeptidase activity mediates NF-kappaB activation through lipid peroxidation in human leukemia U937 cells. Djavaheri-Mergny, M., Accaoui, M.J., Rouillard, D., Wietzerbin, J. Mol. Cell. Biochem. (2002) [Pubmed]
  9. Topology of membrane exposure in the renal cortex slice. Studies of glutathione and maltose cleavage. Arthus, M.F., Bergeron, M., Scriver, C.R. Biochim. Biophys. Acta (1982) [Pubmed]
  10. Proteoliposome interaction with human erythrocyte membranes. Functional implantation of gamma-glutamyl transpeptidase. Sikka, S.C., Green, G.A., Chauhan, V.P., Kalra, V.K. Biochemistry (1982) [Pubmed]
  11. Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulations. Mackic, J.B., Jinagouda, S., McComb, J.G., Weiss, M.H., Kannan, R., Kaplowitz, N., Zlokovic, B.V. Exp. Eye Res. (1996) [Pubmed]
  12. Human erythrocyte gamma-glutamyltransferase in liver diseases. Daniel, D.S., Ramakrishna, B.S., Balasubramanian, K.A. Clin. Chim. Acta (1987) [Pubmed]
  13. gamma-Glutamyltransferase in human diploid fibroblasts and other mammalian cells. Takahashi, S., Seifter, S., Rifas, L. In vitro. (1978) [Pubmed]
  14. Secretion of cysteine and glutathione from mucosa to lumen in rat small intestine. Dahm, L.J., Jones, D.P. Am. J. Physiol. (1994) [Pubmed]
  15. Expression and activity of gamma-glutamyl transpeptidase in the rat epididymis. Hinton, B.T., Palladino, M.A., Mattmueller, D.R., Bard, D., Good, K. Mol. Reprod. Dev. (1991) [Pubmed]
  16. Transfection with gamma-glutamyl transpeptidase enhances recovery from glutathione depletion using extracellular glutathione. Rajpert-De Meyts, E., Shi, M., Chang, M., Robison, T.W., Groffen, J., Heisterkamp, N., Forman, H.J. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
  17. Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. Petric, R., Nicholson, D.W., Ford-Hutchinson, A.W. Biochim. Biophys. Acta (1995) [Pubmed]
  18. On the role of gamma-glutamyltransferase in renal tubular amino acid reabsorption. Wendel, A., Hahn, R., Guder, W.G. Current problems in clinical biochemistry. (1976) [Pubmed]
  19. Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye. Zlokovic, B.V., Mackic, J.B., McComb, J.G., Kaplowitz, N., Weiss, M.H., Kannan, R. Exp. Eye Res. (1994) [Pubmed]
 
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