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Gene Review: 

ndd  -  binds host HU protein and host DNA to the...

Enterobacteria phage T4

 
 
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Disease relevance of ndd

  • The analysis of ndd from six bacteriophages of the T-even family indicated that the protein encoded by this nonessential gene is surprisingly conserved [1].
  • The rapid disruption of the Escherichia coli nucleoid after T4 infection requires the activity of the phage-encoded ndd gene [1].
  • Nuclear disruption occurs normally after infection with unfoldase- and host DNA degradation-deficient but nuclear disruption-proficient (ndd+), T4 phage [2].
 

High impact information on ndd

  • Mutations in the genes for nuclear disruption (ndd), endonuclease IV (denB), and the D1 region of the T4 genome are essential for converting bacteriophage T4 into a generalized transducing phage [3].
  • Determination of the sequence of a 2.5-kb segment including ndd closed the last significant gap in the sequence of the T4 genome [1].
  • This inhibition of the growth of ndd mutants occurs only in the presence of a large (ca. 80-megadalton) plasmid resident in CT447 cells [4].
 

Analytical, diagnostic and therapeutic context of ndd

  • Direct PCR sequencing of the ndd gene of bacteriophage T4: identification of a product involved in bacterial nucleoid disruption [1].

References

  1. Direct PCR sequencing of the ndd gene of bacteriophage T4: identification of a product involved in bacterial nucleoid disruption. Bouet, J.Y., Woszczyk, J., Repoila, F., François, V., Louarn, J.M., Krisch, H.M. Gene (1994) [Pubmed]
  2. Identification and preliminary characterization of a mutant defective in the bacteriophage T4-induced unfolding of the Escherichia coli nucleoid. Snustad, D.P., Tigges, M.A., Parson, K.A., Bursch, C.J., Caron, F.M., Koerner, J.F., Tutas, D.J. J. Virol. (1976) [Pubmed]
  3. Genetic analysis of bacteriophage T4 transducing bacteriophages. Young, K.K., Edlin, G.J., Wilson, G.G. J. Virol. (1982) [Pubmed]
  4. Plasmid-dependent inhibition of growth of bacteriophage T4 ndd mutants. Snustad, D.P., Casey, A.C., Herman, R.E. J. Bacteriol. (1985) [Pubmed]
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