The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

ndd  -  binds host HU protein and host DNA to the...

Enterobacteria phage T4

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ndd

  • The analysis of ndd from six bacteriophages of the T-even family indicated that the protein encoded by this nonessential gene is surprisingly conserved [1].
  • The rapid disruption of the Escherichia coli nucleoid after T4 infection requires the activity of the phage-encoded ndd gene [1].
  • Nuclear disruption occurs normally after infection with unfoldase- and host DNA degradation-deficient but nuclear disruption-proficient (ndd+), T4 phage [2].

High impact information on ndd

  • Mutations in the genes for nuclear disruption (ndd), endonuclease IV (denB), and the D1 region of the T4 genome are essential for converting bacteriophage T4 into a generalized transducing phage [3].
  • Determination of the sequence of a 2.5-kb segment including ndd closed the last significant gap in the sequence of the T4 genome [1].
  • This inhibition of the growth of ndd mutants occurs only in the presence of a large (ca. 80-megadalton) plasmid resident in CT447 cells [4].

Analytical, diagnostic and therapeutic context of ndd

  • Direct PCR sequencing of the ndd gene of bacteriophage T4: identification of a product involved in bacterial nucleoid disruption [1].


  1. Direct PCR sequencing of the ndd gene of bacteriophage T4: identification of a product involved in bacterial nucleoid disruption. Bouet, J.Y., Woszczyk, J., Repoila, F., François, V., Louarn, J.M., Krisch, H.M. Gene (1994) [Pubmed]
  2. Identification and preliminary characterization of a mutant defective in the bacteriophage T4-induced unfolding of the Escherichia coli nucleoid. Snustad, D.P., Tigges, M.A., Parson, K.A., Bursch, C.J., Caron, F.M., Koerner, J.F., Tutas, D.J. J. Virol. (1976) [Pubmed]
  3. Genetic analysis of bacteriophage T4 transducing bacteriophages. Young, K.K., Edlin, G.J., Wilson, G.G. J. Virol. (1982) [Pubmed]
  4. Plasmid-dependent inhibition of growth of bacteriophage T4 ndd mutants. Snustad, D.P., Casey, A.C., Herman, R.E. J. Bacteriol. (1985) [Pubmed]
WikiGenes - Universities