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Gene Review

Cfc1  -  cripto, FRL-1, cryptic family 1

Mus musculus

Synonyms: AV265756, Cryptic protein, b2b970Clo, cryptic
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High impact information on Cfc1

  • Notably, L-R asymmetric expression of Nodal at the lateral edges of the node is still observed in Cryptic mutants, indicating that L-R specification has occurred in the node but not the lateral plate [1].
  • We named this gene Cryptic, based on its predicted protein sequence similarity with Cripto, which encodes an EGF-related growth factor [2].
  • A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation [2].
  • Thus, Cryptic encodes a putative signaling molecule whose expression suggests potential roles in mesoderm and/or neural patterning during gastrulation [2].
  • In the first domain of expression, Cryptic expression is progressively localized to the anterior primitive streak, the head process, and the node and notochordal plate [2].

Biological context of Cfc1


Anatomical context of Cfc1

  • One T-cell epitope was identified between amino acids 33-47 of VP1, which was recognized by virus-reactive T cells. 'Cryptic' epitopes were also present within VP1 at positions 153-167, 166-180, 225-239 and 233-247 [4].

Analytical, diagnostic and therapeutic context of Cfc1


  1. Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Yan, Y.T., Gritsman, K., Ding, J., Burdine, R.D., Corrales, J.D., Price, S.M., Talbot, W.S., Schier, A.F., Shen, M.M. Genes Dev. (1999) [Pubmed]
  2. A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation. Shen, M.M., Wang, H., Leder, P. Development (1997) [Pubmed]
  3. The Major Histocompatibility Complex Haplotypes Dictate and the Background Genes Fine-tune the Dominant versus the Cryptic Response Profile of a T-cell Determinant within a Native Antigen: Relevance to Disease Susceptibility and Vaccination. Sinha, P., Snyder, J.A., Kim, E.Y., Moudgil, K.D. Scand. J. Immunol. (2007) [Pubmed]
  4. Lymphocyte recognition elements on the VP1 protein of Theiler's virus. Usherwood, E.J., Johnston, I.C., Lovelidge, L.J., Tonks, P., Nash, A.A. Immunology (1995) [Pubmed]
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