The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tdgf1  -  teratocarcinoma-derived growth factor 1

Mus musculus

Synonyms: CR1, Cripto, Cripto growth factor, Epidermal growth factor-like Cripto protein, Teratocarcinoma-derived growth factor, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tdgf1


Psychiatry related information on Tdgf1

  • The long latency period suggests that additional genetic alterations are required to facilitate mammary tumor formation in conjunction with CR-1 [5].

High impact information on Tdgf1

  • Before gastrulation, Cripto is asymmetrically expressed in a proximal-distal gradient in the epiblast, and subsequently is expressed in the primitive streak and newly formed embryonic mesoderm [6].
  • A substantial proportion of FoxH1(-/-) embryos failed to orient the anterior-posterior (A-P) axis correctly, as do mice lacking Cripto, a coreceptor for Nodal [7].
  • MSP also caused phagocytosis via the C3b receptor, CR1 [8].
  • Thus, MSP causes direct or indirect activation of two receptors of the mouse resident peritoneal macrophage, CR1 and the C5a receptor [8].
  • 7G6 was able to downregulate CR1 and CR2 on the surface of B cells and, in addition, to inhibit rosette formation with C3d-coated sheep erythrocytes (EC3d) [9].

Biological context of Tdgf1


Anatomical context of Tdgf1


Associations of Tdgf1 with chemical compounds


Regulatory relationships of Tdgf1


Other interactions of Tdgf1

  • We also found intense CR-1 and AR mRNA expression and strong immunoreactivity in seven different carcinogen-induced and eight spontaneous mammary tumors [12].
  • Cripto-1 (CR-1, human; Cr-1, mouse)--also known as teratocarcinoma-derived growth factor-1--is a novel EGF-related protein that induces branching morphogenesis in mammary epithelial cells both in vitro and in vivo and inhibits the expression of various milk proteins [3].
  • But recombinant mature Nodal, unlike uncleaved precursor, can efficiently rescue Cripto expression [17].
  • Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast [21].
  • In vitro differentiated mouse embryonic stem (ES) cells with deletion of the TGF-beta pathway-related factors Smad4 or Cripto exhibited increased numbers of neurons [22].

Analytical, diagnostic and therapeutic context of Tdgf1


  1. Mapping of the mouse Tdgf1 gene and Tdgf pseudogenes. Liguori, G., De Gregorio, L., Tucci, M., Lago, C.T., Barra, A., Dragani, T.A., Persico, M. Mamm. Genome (1997) [Pubmed]
  2. Chemical synthesis, structural modeling, and biological activity of the epidermal growth factor-like domain of human cripto. Lohmeyer, M., Harrison, P.M., Kannan, S., DeSantis, M., O'Reilly, N.J., Sternberg, M.J., Salomon, D.S., Gullick, W.J. Biochemistry (1997) [Pubmed]
  3. Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia. Salomon, D.S., Bianco, C., De Santis, M. Bioessays (1999) [Pubmed]
  4. Expression of cripto, a novel gene of the epidermal growth factor gene family, leads to in vitro transformation of a normal mouse mammary epithelial cell line. Ciardiello, F., Dono, R., Kim, N., Persico, M.G., Salomon, D.S. Cancer Res. (1991) [Pubmed]
  5. Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma. Wechselberger, C., Strizzi, L., Kenney, N., Hirota, M., Sun, Y., Ebert, A., Orozco, O., Bianco, C., Khan, N.I., Wallace-Jones, B., Normanno, N., Adkins, H., Sanicola, M., Salomon, D.S. Oncogene (2005) [Pubmed]
  6. Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. Ding, J., Yang, L., Yan, Y.T., Chen, A., Desai, N., Wynshaw-Boris, A., Shen, M.M. Nature (1998) [Pubmed]
  7. The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Yamamoto, M., Meno, C., Sakai, Y., Shiratori, H., Mochida, K., Ikawa, Y., Saijoh, Y., Hamada, H. Genes Dev. (2001) [Pubmed]
  8. Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity. Skeel, A., Yoshimura, T., Showalter, S.D., Tanaka, S., Appella, E., Leonard, E.J. J. Exp. Med. (1991) [Pubmed]
  9. In vivo inhibition of the antibody response by a complement receptor-specific monoclonal antibody. Heyman, B., Wiersma, E.J., Kinoshita, T. J. Exp. Med. (1990) [Pubmed]
  10. Expression of epidermal growth factor family gene members in early mouse development. Johnson, S.E., Rothstein, J.L., Knowles, B.B. Dev. Dyn. (1994) [Pubmed]
  11. The murine cripto gene: expression during mesoderm induction and early heart morphogenesis. Dono, R., Scalera, L., Pacifico, F., Acampora, D., Persico, M.G., Simeone, A. Development (1993) [Pubmed]
  12. Expression of epidermal growth factor-related proteins in the aged adult mouse mammary gland and their relationship to tumorigenesis. Herrington, E.E., Ram, T.G., Salomon, D.S., Johnson, G.R., Gullick, W.J., Kenney, N., Hosick, H.L. J. Cell. Physiol. (1997) [Pubmed]
  13. Characterization of the mouse Tdgf1 gene and Tdgf pseudogenes. Liguori, G., Tucci, M., Montuori, N., Dono, R., Lago, C.T., Pacifico, F., Armenante, F., Persico, M.G. Mamm. Genome (1996) [Pubmed]
  14. Identification and biological characterization of an epidermal growth factor-related protein: cripto-1. Brandt, R., Normanno, N., Gullick, W.J., Lin, J.H., Harkins, R., Schneider, D., Jones, B.W., Ciardiello, F., Persico, M.G., Armenante, F. J. Biol. Chem. (1994) [Pubmed]
  15. CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor. Walker, F., Orchard, S.G., Jorissen, R.N., Hall, N.E., Zhang, H.H., Hoyne, P.A., Adams, T.E., Johns, T.G., Ward, C., Garrett, T.P., Zhu, H.J., Nerrie, M., Scott, A.M., Nice, E.C., Burgess, A.W. J. Biol. Chem. (2004) [Pubmed]
  16. Cripto-1 indirectly stimulates the tyrosine phosphorylation of erb B-4 through a novel receptor. Bianco, C., Kannan, S., De Santis, M., Seno, M., Tang, C.K., Martinez-Lacaci, I., Kim, N., Wallace-Jones, B., Lippman, M.E., Ebert, A.D., Wechselberger, C., Salomon, D.S. J. Biol. Chem. (1999) [Pubmed]
  17. Extraembryonic proteases regulate Nodal signalling during gastrulation. Beck, S., Le Good, J.A., Guzman, M., Ben Haim, N., Roy, K., Beermann, F., Constam, D.B. Nat. Cell Biol. (2002) [Pubmed]
  18. Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Morkel, M., Huelsken, J., Wakamiya, M., Ding, J., van de Wetering, M., Clevers, H., Taketo, M.M., Behringer, R.R., Shen, M.M., Birchmeier, W. Development (2003) [Pubmed]
  19. Cripto-1 induces apoptosis in HC-11 mouse mammary epithelial cells. De Santis, M.L., Martinez-Lacaci, I., Bianco, C., Seno, M., Wallace-Jones, B., Kim, N., Ebert, A., Wechselberger, C., Salomon, D.S. Cell Death Differ. (2000) [Pubmed]
  20. Identification of Cripto-1 in human milk. Bianco, C., Wechselberger, C., Ebert, A., Khan, N.I., Sun, Y., Salomon, D.S. Breast Cancer Res. Treat. (2001) [Pubmed]
  21. Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast. Kimura, C., Shen, M.M., Takeda, N., Aizawa, S., Matsuo, I. Dev. Biol. (2001) [Pubmed]
  22. Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells. Sonntag, K.C., Simantov, R., Björklund, L., Cooper, O., Pruszak, J., Kowalke, F., Gilmartin, J., Ding, J., Hu, Y.P., Shen, M.M., Isacson, O. Mol. Cell. Neurosci. (2005) [Pubmed]
  23. Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development. Minchiotti, G., Parisi, S., Liguori, G., Signore, M., Lania, G., Adamson, E.D., Lago, C.T., Persico, M.G. Mech. Dev. (2000) [Pubmed]
  24. CRIPTO-1: a novel target for therapeutic intervention in human carcinoma. Normanno, N., De Luca, A., Maiello, M.R., Bianco, C., Mancino, M., Strizzi, L., Arra, C., Ciardiello, F., Agrawal, S., Salomon, D.S. Int. J. Oncol. (2004) [Pubmed]
  25. Cripto: a novel target for antibody-based cancer immunotherapy. Xing, P.X., Hu, X.F., Pietersz, G.A., Hosick, H.L., McKenzie, I.F. Cancer Res. (2004) [Pubmed]
  26. Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. Xu, C., Liguori, G., Persico, M.G., Adamson, E.D. Development (1999) [Pubmed]
WikiGenes - Universities