Disease relevance of CFC1

• CFC1 mutations in patients with transposition of the great arteries and double-outlet right ventricle [1].
• We conclude that CFC1 variants could be a rare cause of congenital heart disease in patients without laterality defects [2].
• Inhibition of Experimental Metastasis by Targeting the HUIV26 Cryptic Epitope in Collagen [3].
• Analysis of Core Housekeeping and Virulence Genes Reveals Cryptic Lineages of Clostridium perfringens That Are Associated With Distinct Disease Presentations [4].
• (2) Cryptic pregnancy could result from missed spontaneous abortions of low-quality fetuses [5].

Psychiatry related information on CFC1

• V(D)J Recombinase-Mediated Processing of Coding Junctions at Cryptic Recombination Signal Sequences in Peripheral T Cells during Human Development [6].
• OBJECTIVE: Cryptic subtelomeric chromosome rearrangements account for 6% to 10% of idiopathic mental retardation [7].

High impact information on CFC1

• Here we identify loss-of-function mutations in human CFC1 (encoding the CRYPTIC protein) in patients with heterotaxic phenotypes (randomized organ positioning) [8].
• We hypothesized that a subset of patients with similar types of congenital heart disease---namely, transposition of the great arteries and double-outlet right ventricle, in the absence of laterality defects---would also have CFC1 mutations [1].
• Computational Sampling of a Cryptic Drug Binding Site in a Protein Receptor: Explicit Solvent Molecular Dynamics and Inhibitor Docking to p38 MAP Kinase [9].
• The Major Histocompatibility Complex Haplotypes Dictate and the Background Genes Fine-tune the Dominant versus the Cryptic Response Profile of a T-cell Determinant within a Native Antigen: Relevance to Disease Susceptibility and Vaccination [10].
• Conclusions: Cryptic rearrangement of chromosomes 17 and 22 should be suspected in variant ring chromosomes and translocations [11].

Biological context of CFC1

• Morphological and Genetic Variation Indicate Cryptic Species Within Lamarck's Little Sea Star, Parvulastra (=Patiriella) exigua [12].

Associations of CFC1 with chemical compounds

• Maize Ear Rot and Moniliformin Contamination by Cryptic Species of Fusarium subglutinans [13].

Other interactions of CFC1

• Our analysis of the CFC1 gene in 167 patients with congenital heart disease revealed a novel A145T missense variant in 3 patients with type II atrial septal defect [2].

References