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Gene Review:

sieB - SieB

Enterobacteria phage P22

Ranade, K. et al., Joshi, A. et al., Ranade, K. et al.

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Disease relevance of sieB

One of these genes, sieB, aborts the lytic development of some phages [1].
Both sieA and sieB genes of the resident P22 prophage are required to exclude the superinfecting MB78 phage, whereas all temperate phages related to P22 are excluded by either one or both of the genes individually [2].
The superinfection exclusion gene (sieB) of Salmonella phage P22 was mapped with phage deletion mutants [3].
The sieB gene of coliphage lambda was also identified [3].

High impact information on sieB

Superinfection exclusion (sieB) genes of bacteriophages P22 and lambda [3].
The transcription start site of sieB was identified by the use of an RNase protection assay [3].
On the basis of deletion and amber mutant phenotypes, the second of these six sites was inferred to be the translation initiation site of the sieB gene [3].
The sieB gene encodes a polypeptide with 192 amino acid residues with a calculated molecular weight of 22,442, which is in reasonable agreement with that estimated from polyacrylamide gels [3].

References

A switch in translation mediated by an antisense RNA. Ranade, K., Poteete, A.R. Genes Dev. (1993) [Pubmed]
MB78, a virulent bacteriophage of Salmonella typhimurium. Joshi, A., Siddiqi, J.Z., Rao, G.R., Chakravorty, M. J. Virol. (1982) [Pubmed]
Superinfection exclusion (sieB) genes of bacteriophages P22 and lambda. Ranade, K., Poteete, A.R. J. Bacteriol. (1993) [Pubmed]

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