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Gene Review

Ddx3x  -  DEAD/H (Asp-Glu-Ala-Asp/His) box...

Mus musculus

Synonyms: ATP-dependent RNA helicase DDX3X, D1Pas1-related sequence 2, D1Pas1-rs2, DEAD box RNA helicase DEAD3, DEAD box protein 3, X-chromosomal, ...
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High impact information on Ddx3x

  • In situ hybridization revealed that Ddx3x mRNA was expressed in almost every cell in mouse testis, suggesting that Ddx3x is involved in spermatogenesis [1].
  • ERH is expressed in oocytes and is a ubiquitous mRNA in the 9 days-post-conception embryo, and at later stages of development shows a more restricted pattern of expression in brain and kidney [2].
  • Here we describe the isolation and characterization of an embryonic RNA helicase gene, ERH, which maps to mouse chromosome 1 and encodes a new member of the DEAD box family of proteins [2].
  • Although the level of expression of Dby was much lower than its X chromosome homolog, Ddx3 (also known as Ddx3x) in all samples examined, the pattern of expression of the 2 genes was comparable [3].


  1. Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation. Sekiguchi, T., Iida, H., Fukumura, J., Nishimoto, T. Exp. Cell Res. (2004) [Pubmed]
  2. The embryonic RNA helicase gene (ERH): a new member of the DEAD box family of RNA helicases. Sowden, J., Putt, W., Morrison, K., Beddington, R., Edwards, Y. Biochem. J. (1995) [Pubmed]
  3. Structural characterization and expression studies of dby and its homologs in the mouse. Vong, Q.P., Li, Y., Lau, Y.F., Dym, M., Rennert, O.M., Chan, W.Y. J. Androl. (2006) [Pubmed]
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