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Gene Review

bel  -  belle

Drosophila melanogaster

Synonyms: ATP-dependent RNA helicase bel, BEL, Bel, CG9748, DmRH6, ...
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Disease relevance of bel

  • Some BEL-like elements have captured an envelope gene, probably from other retroelements in some cases but from a phlebovirus in one case [1].

High impact information on bel

  • Other Drosophila transposons also appear to mediate chromosome restructuring by ectopic recombination; these include the retrotransposons BEL, roo, Doc and I and the foldback element FB [2].
  • Consistent with an essential cellular function, strong loss of function mutations in bel are recessive lethal with a larval growth defect phenotype [3].
  • We find that Bel and Vas colocalize in nuage and at the oocyte posterior during oogenesis, and that bel function is required for female fertility [3].
  • CONCLUSION: Sinbad is a Pao/BEL type retrotransposon from the genome of S. mansoni [4].
  • BACKGROUND: Of the major families of long terminal repeat (LTR) retrotransposons, the Pao/BEL family is probably the least well studied [4].

Biological context of bel

  • The Pao/BEL group appears to be comprised of at least five discrete subfamilies, which tend to cluster with host species phylogeny [4].


  1. New BEL-like LTR-retrotransposons in Fugu rubripes, Caenorhabditis elegans, and Drosophila melanogaster. Frame, I.G., Cutfield, J.F., Poulter, R.T. Gene (2001) [Pubmed]
  2. Gross chromosome rearrangements mediated by transposable elements in Drosophila melanogaster. Lim, J.K., Simmons, M.J. Bioessays (1994) [Pubmed]
  3. Belle is a Drosophila DEAD-box protein required for viability and in the germ line. Johnstone, O., Deuring, R., Bock, R., Linder, P., Fuller, M.T., Lasko, P. Dev. Biol. (2005) [Pubmed]
  4. The Sinbad retrotransposon from the genome of the human blood fluke, Schistosoma mansoni, and the distribution of related Pao-like elements. Copeland, C.S., Mann, V.H., Morales, M.E., Kalinna, B.H., Brindley, P.J. BMC Evol. Biol. (2005) [Pubmed]
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