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Gene Review:

ENPP6 - ectonucleotide pyrophosphatase/phosphodies...

Homo sapiens

Synonyms: Choline-specific glycerophosphodiester phosphodiesterase, E-NPP 6, Ectonucleotide pyrophosphatase/phosphodiesterase family member 6, GPC-Cpde, Glycerophosphocholine cholinephosphodiesterase, ...

Sakagami, H. et al.

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High impact information on ENPP6

Here we show that the sixth member of the NPP family, NPP6, is a choline-specific glycerophosphodiester phosphodiesterase [1].
NPP6 showed a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids [1].
The present results suggest that NPP6 has a specific role through the hydrolysis of polyunsaturated LPC, glycerophosphorylcholine, or sphingosylphosphorylcholine in these organs [1].
Recombinant NPP6 efficiently hydrolyzed the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, but not the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate [1].
When expressed in HeLa cells, NPP6 was detected in both the cells and the cell culture medium as judged by Western blotting and by enzymatic activity [1].

References

Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. Sakagami, H., Aoki, J., Natori, Y., Nishikawa, K., Kakehi, Y., Natori, Y., Arai, H. J. Biol. Chem. (2005) [Pubmed]

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