The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1NSKNF     2-[[(E,2R,3S)-2-amino-3- hydroxy-octadec-4...

This record was replaced with 5311446.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 2-[[(E,2R,3S)-2-amino-3-hydroxy-octadec-4-enoxy]-hydroxy-phosphoryl]oxyethyl-trimethyl-azanium


High impact information on 2-[[(E,2R,3S)-2-amino-3-hydroxy-octadec-4-enoxy]-hydroxy-phosphoryl]oxyethyl-trimethyl-azanium


Chemical compound and disease context of 2-[[(E,2R,3S)-2-amino-3-hydroxy-octadec-4-enoxy]-hydroxy-phosphoryl]oxyethyl-trimethyl-azanium


Biological context of 2-[[(E,2R,3S)-2-amino-3-hydroxy-octadec-4-enoxy]-hydroxy-phosphoryl]oxyethyl-trimethyl-azanium


Anatomical context of 2-[[(E,2R,3S)-2-amino-3-hydroxy-octadec-4-enoxy]-hydroxy-phosphoryl]oxyethyl-trimethyl-azanium


Associations of 2-[[(E,2R,3S)-2-amino-3-hydroxy-octadec-4-enoxy]-hydroxy-phosphoryl]oxyethyl-trimethyl-azanium with other chemical compounds


Gene context of 2-[[(E,2R,3S)-2-amino-3-hydroxy-octadec-4-enoxy]-hydroxy-phosphoryl]oxyethyl-trimethyl-azanium


Analytical, diagnostic and therapeutic context of 2-[[(E,2R,3S)-2-amino-3-hydroxy-octadec-4-enoxy]-hydroxy-phosphoryl]oxyethyl-trimethyl-azanium


  1. Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells. Beil, M., Micoulet, A., von Wichert, G., Paschke, S., Walther, P., Omary, M.B., Van Veldhoven, P.P., Gern, U., Wolff-Hieber, E., Eggermann, J., Waltenberger, J., Adler, G., Spatz, J., Seufferlein, T. Nat. Cell Biol. (2003) [Pubmed]
  2. Pertussis toxin inhibits phospholipase C activation and Ca2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids. Okajima, F., Kondo, Y. J. Biol. Chem. (1995) [Pubmed]
  3. Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis. Okamoto, R., Arikawa, J., Ishibashi, M., Kawashima, M., Takagi, Y., Imokawa, G. J. Lipid Res. (2003) [Pubmed]
  4. Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions. Yamada, T., Okajima, F., Ohwada, S., Kondo, Y. Cell. Mol. Life Sci. (1997) [Pubmed]
  5. Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry. Thomas, G.D., Snetkov, V.A., Patel, R., Leach, R.M., Aaronson, P.I., Ward, J.P. Cardiovasc. Res. (2005) [Pubmed]
  6. Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts. Desai, N.N., Carlson, R.O., Mattie, M.E., Olivera, A., Buckley, N.E., Seki, T., Brooker, G., Spiegel, S. J. Cell Biol. (1993) [Pubmed]
  7. The End2 mutation in CHO cells slows the exit of transferrin receptors from the recycling compartment but bulk membrane recycling is unaffected. Presley, J.F., Mayor, S., Dunn, K.W., Johnson, L.S., McGraw, T.E., Maxfield, F.R. J. Cell Biol. (1993) [Pubmed]
  8. Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process. Mayor, S., Presley, J.F., Maxfield, F.R. J. Cell Biol. (1993) [Pubmed]
  9. Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes. Guo, Z., Liliom, K., Fischer, D.J., Bathurst, I.C., Tomei, L.D., Kiefer, M.C., Tigyi, G. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  10. A role for G protein-coupled lysophospholipid receptors in sphingolipid-induced Ca2+ signaling in MC3T3-E1 osteoblastic cells. Lyons, J.M., Karin, N.J. J. Bone Miner. Res. (2001) [Pubmed]
  11. Lysophospholipids activate ovarian and breast cancer cells. Xu, Y., Fang, X.J., Casey, G., Mills, G.B. Biochem. J. (1995) [Pubmed]
  12. Sphingosylphosphorylcholine is a potent inducer of intercellular adhesion molecule-1 expression in human keratinocytes. Imokawa, G., Takagi, Y., Higuchi, K., Kondo, H., Yada, Y. J. Invest. Dermatol. (1999) [Pubmed]
  13. Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine. Altmann, C., Steenpass, V., Czyborra, P., Hein, P., Michel, M.C. Br. J. Pharmacol. (2003) [Pubmed]
  14. Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. Meyer zu Heringdorf, D., Lass, H., Kuchar, I., Lipinski, M., Alemany, R., Rümenapp, U., Jakobs, K.H. Eur. J. Pharmacol. (2001) [Pubmed]
  15. Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor. Signaling pathways and formation of a p130(cas)-Crk complex. Casamassima, A., Rozengurt, E. J. Biol. Chem. (1997) [Pubmed]
  16. Signaling events during induction of plasminogen activator inhibitor-1 expression by sphingosylphosphorylcholine in cultured human dermal fibroblasts. Kye, K.C., Chae, E.K., Piao, Y.J., Park, S., Park, J.K., Kim, C.D., Lee, J.H., Suhr, K.B. J. Invest. Dermatol. (2004) [Pubmed]
  17. Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes. Sekiguchi, K., Yokoyama, T., Kurabayashi, M., Okajima, F., Nagai, R. Circ. Res. (1999) [Pubmed]
  18. Characterization of a novel intracellular sphingolipid-gated Ca(2+)-permeable channel from rat basophilic leukemia cells. Kindman, L.A., Kim, S., McDonald, T.V., Gardner, P. J. Biol. Chem. (1994) [Pubmed]
  19. Sphingosylphosphorylcholine rapidly induces tyrosine phosphorylation of p125FAK and paxillin, rearrangement of the actin cytoskeleton and focal contact assembly. Requirement of p21rho in the signaling pathway. Seufferlein, T., Rozengurt, E. J. Biol. Chem. (1995) [Pubmed]
  20. Sphingosylphosphorylcholine activation of mitogen-activated protein kinase in Swiss 3T3 cells requires protein kinase C and a pertussis toxin-sensitive G protein. Seufferlein, T., Rozengurt, E. J. Biol. Chem. (1995) [Pubmed]
  21. Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-{beta}-dependent mechanism. Jeon, E.S., Moon, H.J., Lee, M.J., Song, H.Y., Kim, Y.M., Bae, Y.C., Jung, J.S., Kim, J.H. J. Cell. Sci. (2006) [Pubmed]
  22. Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. Clair, T., Aoki, J., Koh, E., Bandle, R.W., Nam, S.W., Ptaszynska, M.M., Mills, G.B., Schiffmann, E., Liotta, L.A., Stracke, M.L. Cancer Res. (2003) [Pubmed]
  23. Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). Brailoiu, E., Patel, S., Dun, N.J. Biochem. J. (2003) [Pubmed]
  24. Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux. Nofer, J.R., Fobker, M., Höbbel, G., Voss, R., Wolinska, I., Tepel, M., Zidek, W., Junker, R., Seedorf, U., von Eckardstein, A., Assmann, G., Walter, M. Biochemistry (2000) [Pubmed]
  25. Sphingosylphosphorylcholine stimulates proliferation and upregulates cell surface-associated plasminogen activator activity in cultured human keratinocytes. Wakita, H., Matsushita, K., Nishimura, K., Tokura, Y., Furukawa, F., Takigawa, M. J. Invest. Dermatol. (1998) [Pubmed]
  26. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. Van Brocklyn, J.R., Gräler, M.H., Bernhardt, G., Hobson, J.P., Lipp, M., Spiegel, S. Blood (2000) [Pubmed]
  27. Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK. Jeon, E.S., Song, H.Y., Kim, M.R., Moon, H.J., Bae, Y.C., Jung, J.S., Kim, J.H. J. Lipid Res. (2006) [Pubmed]
  28. Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes. Kim, D.S., Park, S.H., Kwon, S.B., Park, E.S., Huh, C.H., Youn, S.W., Park, K.C. Pigment Cell Res. (2006) [Pubmed]
  29. EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16. Okamoto, H., Takuwa, N., Yatomi, Y., Gonda, K., Shigematsu, H., Takuwa, Y. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  30. GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. Kim, K.S., Ren, J., Jiang, Y., Ebrahem, Q., Tipps, R., Cristina, K., Xiao, Y.J., Qiao, J., Taylor, K.L., Lum, H., Anand-Apte, B., Xu, Y. FASEB J. (2005) [Pubmed]
  31. Purification of a newly identified alkaline sphingomyelinase in human bile and effects of bile salts and phosphatidylcholine on enzyme activity. Duan, R.D., Nilsson, A. Hepatology (1997) [Pubmed]
  32. Evidence that lipoproteins are carriers of bioactive factors. Sachinidis, A., Kettenhofen, R., Seewald, S., Gouni-Berthold, I., Schmitz, U., Seul, C., Ko, Y., Vetter, H. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  33. Sphingosylphosphorylcholine stimulates contraction of fibroblast-embedded collagen gel. Suhr, K.B., Tsuboi, R., Ogawa, H. Br. J. Dermatol. (2000) [Pubmed]
  34. The influence of zinc on the modulatory effect of sphingosylphosphorylcholine on Kv1.3 channels in human T lymphocytes. Teisseyre, A., Michalak, K. Eur. Biophys. J. (2004) [Pubmed]
  35. Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria. Suresh, S., Spatz, J., Mills, J.P., Micoulet, A., Dao, M., Lim, C.T., Beil, M., Seufferlein, T. Acta biomaterialia. (2005) [Pubmed]
WikiGenes - Universities