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Gene Review:

Trdmt1 - tRNA aspartic acid methyltransferase 1

Mus musculus

Synonyms: DNA (cytosine-5)-methyltransferase-like protein 2, DNA MTase homolog MmuIIP, DNA methyltransferase homolog MmuIIP, Dnmt2, M.MmuIIP, ...

Goll, M.G. et al., Taylor, A.B. et al.

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High impact information on Trdmt1

The hydrophobic side chains of five active-site residues (Met-2, Ile-64, Met-101, Val-106, and Phe-113) and the phenyl moiety of Tyr-95' are responsible for the binding of the phenyl group [1].
The function of DNMT2 is highly conserved, and human DNMT2 protein restored methylation in vitro to tRNA(Asp) from Dnmt2-deficient strains of mouse, Arabidopsis thaliana, and Drosophila melanogaster in a manner that was dependent on preexisting patterns of modified nucleosides [2].
The sequence and the structure of DNA methyltransferase-2 (Dnmt2) bear close affinities to authentic DNA cytosine methyltransferases [2].

References

Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition. Taylor, A.B., Johnson, W.H., Czerwinski, R.M., Li, H.S., Hackert, M.L., Whitman, C.P. Biochemistry (1999) [Pubmed]
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Goll, M.G., Kirpekar, F., Maggert, K.A., Yoder, J.A., Hsieh, C.L., Zhang, X., Golic, K.G., Jacobsen, S.E., Bestor, T.H. Science (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP012836	Anopheles gambiae str. PEST
AgaP_AGAP004101	Anopheles gambiae str. PEST
DNMT2	Arabidopsis thaliana
TRDMT1	Bos taurus
TRDMT1	Canis lupus familiaris
trdmt1	Danio rerio
Mt2	Drosophila melanogaster
TRDMT1	Gallus gallus
TRDMT1	Homo sapiens
TRDMT1	Pan troglodytes
Trdmt1	Rattus norvegicus
pmt1	Schizosaccharomyces pombe 972h-
trdmt1	Xenopus (Silurana) tropicalis

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