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Gene Review

Mt2  -  Methyltransferase 2

Drosophila melanogaster

Synonyms: CG10692, DNMT, DNMT2, DmMT2, Dmel\CG10692, ...
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High impact information on Dnmt2


Biological context of Dnmt2


Associations of Dnmt2 with chemical compounds

  • DnmA belongs to the Dnmt2 subfamily and contains all the catalytic motifs necessary for cytosine methyltransferases [6].


  1. Drosophila proteins related to vertebrate DNA (5-cytosine) methyltransferases. Hung, M.S., Karthikeyan, N., Huang, B., Koo, H.C., Kiger, J., Shen, C.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. A Dnmt2-like protein mediates DNA methylation in Drosophila. Kunert, N., Marhold, J., Stanke, J., Stach, D., Lyko, F. Development (2003) [Pubmed]
  3. Conservation of DNA methylation in dipteran insects. Marhold, J., Rothe, N., Pauli, A., Mund, C., Kuehle, K., Brueckner, B., Lyko, F. Insect Mol. Biol. (2004) [Pubmed]
  4. Comparative analysis of DNA methylation patterns in transgenic Drosophila overexpressing mouse DNA methyltransferases. Mund, C., Musch, T., Strödicke, M., Assmann, B., Li, E., Lyko, F. Biochem. J. (2004) [Pubmed]
  5. The eukaryotic DNMT2 genes encode a new class of cytosine-5 DNA methyltransferases. Tang, L.Y., Reddy, M.N., Rasheva, V., Lee, T.L., Lin, M.J., Hung, M.S., Shen, C.K. J. Biol. Chem. (2003) [Pubmed]
  6. Developmentally regulated DNA methylation in Dictyostelium discoideum. Katoh, M., Curk, T., Xu, Q., Zupan, B., Kuspa, A., Shaulsky, G. Eukaryotic Cell (2006) [Pubmed]
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