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Gene Review

TRDMT1  -  tRNA aspartic acid methyltransferase 1

Homo sapiens

Synonyms: DMNT2, DNA (cytosine-5)-methyltransferase-like protein 2, DNA MTase homolog HsaIIP, DNA methyltransferase homolog HsaIIP, DNMT2, ...
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Disease relevance of TRDMT1

  • The average level of mRNA for DNMT1 and DNMT3b in colorectal and stomach cancers was significantly higher than in corresponding non-cancerous mucosae, whereas the average level of mRNA for DNMT2 was significantly lower in colorectal and stomach cancers than in non-cancerous tissue [1].
  • We also found two dnmt2 members in the bacterial genus Geobacter, suggesting that horizontal transfers of MTases occurred between eukaryotes and prokaryotes [2].

High impact information on TRDMT1

  • DNMT1b is a splice variant of the predominant maintenance activity DNMT1, while DNMT2 is a well-conserved protein with homologs in plants, yeast, Drosophila, humans, and mice [3].
  • We used an antibody-based method to identify specific endogenous DNMTs (DNMT1, DNMT1b, DNMT2, DNMT3a, and DNMT3b) that stably and selectively bind to genomic DNA containing 5-aza-2'-deoxycytidine (aza-dC) in vivo [3].
  • The data here suggest that DNMT2 is active in vivo when the endogenous genome is the target, both in human and mouse cell lines [3].
  • The human DNMT2 gene was mapped to chromosome 10p12-10p14 in a panel of radiation hybrids [4].
  • Dnmt2 produces multiple mRNA species that are present at low levels in all tissues of human and mouse and is not restricted to those cell types known to be active in de novo methylation [4].

Biological context of TRDMT1


Associations of TRDMT1 with chemical compounds


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