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Gene Review

GAB3  -  GRB2-associated binding protein 3

Homo sapiens

Synonyms: GRB2-associated binder 3, GRB2-associated-binding protein 3, Growth factor receptor bound protein 2-associated protein 3
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High impact information on GAB3

  • These results suggest that Gab3 is important for macrophage differentiation and that differentiation requires the early phosphorylation of Gab2 followed by induction and subsequent phosphorylation of Gab3 [1].
  • Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation [2].
  • During M-CSF-stimulated macrophage differentiation of mouse bone marrow cells, Mona and Gab3 expression is coinduced, these proteins interact, and Mona engages in multimolecular complexes [2].
  • Gab3 is more restricted to the hematopoietic tissues such as spleen and thymus but is detectable at progressively lower levels within heart, kidney, uterus, and brain [1].

Biological context of GAB3

  • Gab3 contains an amino-terminal pleckstrin homology domain, multiple potential sites for tyrosine phosphorylation and SH2 domain binding, and two major polyproline motifs potentially interacting with SH3 domains [1].


  1. Gab3, a new DOS/Gab family member, facilitates macrophage differentiation. Wolf, I., Jenkins, B.J., Liu, Y., Seiffert, M., Custodio, J.M., Young, P., Rohrschneider, L.R. Mol. Cell. Biol. (2002) [Pubmed]
  2. Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation. Bourgin, C., Bourette, R.P., Arnaud, S., Liu, Y., Rohrschneider, L.R., Mouchiroud, G. Mol. Cell. Biol. (2002) [Pubmed]
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