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Gene Review:

RNF32 - ring finger protein 32

Homo sapiens

Synonyms: FKSG33, HSD15, LMBR2, RING finger protein 32

van Baren, M.J. et al.

van Baren, van der Linde, Breedveld, Baarends, Rizzu, de Graaff, Oostra, Heutink,

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High impact information on RNF32

In humans, RNF32 overlaps with a processed retroposon located on the opposite strand, C7orf13 [1].
We have cloned and characterized a novel gene, RNF32, located on chromosome 7q36 [1].
A double RING-H2 domain in RNF32, a gene expressed during sperm formation [1].
RNF32 is expressed during spermatogenesis, most likely in spermatocytes and/or in spermatids, suggesting a possible role in sperm formation [1].
RNF32 is contained in 37 kb of genomic DNA and consists of 9 constitutive and 8 alternatively spliced exons, most of which are alternative first exons [1].

Biological context of RNF32

RNF32 is specifically expressed in testis and ovary, whereas C7orf13 is testis-specific, suggesting that its expression may be regulated by elements in the RNF32 promoter region [1].

References

A double RING-H2 domain in RNF32, a gene expressed during sperm formation. van Baren, M.J., van der Linde, H.C., Breedveld, G.J., Baarends, W.M., Rizzu, P., de Graaff, E., Oostra, B.A., Heutink, P. Biochem. Biophys. Res. Commun. (2002) [Pubmed]

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