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Gene Review

RNF6  -  ring finger protein (C3H2C3 type) 6

Homo sapiens

Synonyms: DKFZp686P0776, E3 ubiquitin-protein ligase RNF6, SPG2
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Disease relevance of RNF6


High impact information on RNF6

  • SCF and Cullin/Ring H2-based ubiquitin ligases [5].
  • Here it is shown that the endogenous VHL complex in rat liver also includes Rbx1, an evolutionarily conserved protein that contains a RING-H2 fingerlike motif and that interacts with Cullins [6].
  • The regions of similarity among the UBR family members include a putative zinc finger and RING-H2 finger, another zinc-binding domain [7].
  • Identification of multiple somatic mutations in RNF6 suggests that RNF6 is a potential tumor suppressor gene involved in the pathogenesis of ESCC [1].
  • In contrast, three somatic mutations in the RNF6 gene were detected in the ESCC primary tumors, and one mutation was also found in a tumor cell line [1].

Biological context of RNF6

  • FISH and physical mapping indicated that RNF6 is located at 13q12.2 close to marker D13S1121, and it is oriented from telomere to centromere [2].
  • We conclude that the RING-H2 finger domain of EL5 is the E2 binding site of EL5 [3].
  • We introduced point mutations into the EL5 RING-H2 finger so that residues that functionally interact with OsUBC5b could be identified when assayed for ubiquitination activity in vitro [8].
  • Both genes encode a protein of 643 amino acids containing a seven transmembrane domain, a RING-H2 motif and a leucine zipper motif and showed a 94.7% amino acid sequence identity to each other [9].
  • The expression of LeATL6, an ortholog of Arabidopsis ATL6 that encodes a RING-H2 finger protein, was induced in tomato roots treated with a cell wall protein fraction (CWP) elicitor of the biocontrol agent Pythium oligandrum [10].

Anatomical context of RNF6


Associations of RNF6 with chemical compounds

  • APC11 contains a RING-H2-finger domain, which includes one histidine and seven cysteine residues that coordinate two Zn(2+) ions [14].
  • The domains that interacted with ANAC contain a glutamic acid residue in a position corresponding to a proline in many RING-H2 domains [15].
  • A variant of the RING domain is the RING-H2 domain, in which one of the cysteines is replaced by a histidine [16].
  • We cloned human and mouse entire kf-1 cDNAs encoding conserved 79 kDa proteins containing a zinc-binding RING-H2 finger motif at the carboxy-terminus as found in acetylcholine receptor-associated protein (RAPsyn) [17].

Physical interactions of RNF6


Other interactions of RNF6


Analytical, diagnostic and therapeutic context of RNF6


  1. Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma. Lo, H.S., Hu, N., Gere, S., Lu, N., Su, H., Goldstein, A.M., Taylor, P.R., Lee, M.P. Cancer Res. (2002) [Pubmed]
  2. Cloning and characterization of RNF6, a novel RING finger gene mapping to 13q12. Macdonald, D.H., Lahiri, D., Sampath, A., Chase, A., Sohal, J., Cross, N.C. Genomics (1999) [Pubmed]
  3. High precision NMR structure and function of the RING-H2 finger domain of EL5, a rice protein whose expression is increased upon exposure to pathogen-derived oligosaccharides. Katoh, S., Hong, C., Tsunoda, Y., Murata, K., Takai, R., Minami, E., Yamazaki, T., Katoh, E. J. Biol. Chem. (2003) [Pubmed]
  4. The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. Subramaniam, V., Li, H., Wong, M., Kitching, R., Attisano, L., Wrana, J., Zubovits, J., Burger, A.M., Seth, A. Br. J. Cancer (2003) [Pubmed]
  5. SCF and Cullin/Ring H2-based ubiquitin ligases. Deshaies, R.J. Annu. Rev. Cell Dev. Biol. (1999) [Pubmed]
  6. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Kamura, T., Koepp, D.M., Conrad, M.N., Skowyra, D., Moreland, R.J., Iliopoulos, O., Lane, W.S., Kaelin, W.G., Elledge, S.J., Conaway, R.C., Harper, J.W., Conaway, J.W. Science (1999) [Pubmed]
  7. The mouse and human genes encoding the recognition component of the N-end rule pathway. Kwon, Y.T., Reiss, Y., Fried, V.A., Hershko, A., Yoon, J.K., Gonda, D.K., Sangan, P., Copeland, N.G., Jenkins, N.A., Varshavsky, A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. Active site residues and amino acid specificity of the ubiquitin carrier protein-binding RING-H2 finger domain. Katoh, S., Tsunoda, Y., Murata, K., Minami, E., Katoh, E. J. Biol. Chem. (2005) [Pubmed]
  9. The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. Shimizu, K., Tani, M., Watanabe, H., Nagamachi, Y., Niinaka, Y., Shiroishi, T., Ohwada, S., Raz, A., Yokota, J. FEBS Lett. (1999) [Pubmed]
  10. The LeATL6-associated ubiquitin/proteasome system may contribute to fungal elicitor-activated defense response via the jasmonic acid-dependent signaling pathway in tomato. Hondo, D., Hase, S., Kanayama, Y., Yoshikawa, N., Takenaka, S., Takahashi, H. Mol. Plant Microbe Interact. (2007) [Pubmed]
  11. Goliath, a ring-H2 mitochondrial protein, regulated by luteinizing hormone/human chorionic gonadotropin in rat leydig cells. Guais, A., Solhonne, B., Melaine, N., Guellaen, G., Bulle, F. Biol. Reprod. (2004) [Pubmed]
  12. The Ring-H2 finger motif of CKBBP1/SAG is necessary for interaction with protein kinase CKII and optimal cell proliferation. Kim, Y.S., Ha, K.S., Kim, Y.H., Bae, Y.S. J. Biochem. Mol. Biol. (2002) [Pubmed]
  13. The role of PRAJA and ELF in TGF-beta signaling and gastric cancer. Mishra, L., Katuri, V., Evans, S. Cancer Biol. Ther. (2005) [Pubmed]
  14. The RING-H2-finger protein APC11 as a target of hydrogen peroxide. Chang, T.S., Jeong, W., Lee, D.Y., Cho, C.S., Rhee, S.G. Free Radic. Biol. Med. (2004) [Pubmed]
  15. Interactions between plant RING-H2 and plant-specific NAC (NAM/ATAF1/2/CUC2) proteins: RING-H2 molecular specificity and cellular localization. Greve, K., La Cour, T., Jensen, M.K., Poulsen, F.M., Skriver, K. Biochem. J. (2003) [Pubmed]
  16. A double RING-H2 domain in RNF32, a gene expressed during sperm formation. van Baren, M.J., van der Linde, H.C., Breedveld, G.J., Baarends, W.M., Rizzu, P., de Graaff, E., Oostra, B.A., Heutink, P. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  17. Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus. Yasojima, K., Tsujimura, A., Mizuno, T., Shigeyoshi, Y., Inazawa, J., Kikuno, R., Kuma, K., Ohkubo, K., Hosokawa, Y., Ibata, Y., Abe, T., Miyata, T., Matsubara, K., Nakajima, K., Hashimoto-Gotoh, T. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  18. RNF11 is a multifunctional modulator of growth factor receptor signalling and transcriptional regulation. Azmi, P., Seth, A. Eur. J. Cancer (2005) [Pubmed]
  19. hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase. Kreft, S.G., Nassal, M. J. Cell. Sci. (2003) [Pubmed]
  20. hVPS41 is expressed in multiple isoforms and can associate with vesicles through a RING-H2 finger motif. McVey Ward, D., Radisky, D., Scullion, M.A., Tuttle, M.S., Vaughn, M., Kaplan, J. Exp. Cell Res. (2001) [Pubmed]
  21. Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p. Chan, A.H., Lee, S.M., Chim, S.S., Kok, L.D., Waye, M.M., Lee, C.Y., Fung, K.P., Tsui, S.K. J. Cell. Biochem. (2001) [Pubmed]
  22. The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation. Chen, A., Wu, K., Fuchs, S.Y., Tan, P., Gomez, C., Pan, Z.Q. J. Biol. Chem. (2000) [Pubmed]
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