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Gene Review: 

Siah1  -  siah E3 ubiquitin protein ligase 1

Rattus norvegicus

Synonyms: E3 ubiquitin-protein ligase SIAH1, SIAH, Seven in absentia homolog 1, Siah-1, Siah-1a, ...
 
 
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Disease relevance of Siah1a

  • In particular, a recent report that DCC is regulated through the ubiquitin-proteosome system via Siah/Sina proteins, is consistent with a potential involvement in genetic and sporadic forms of Parkinson's disease [1].
 

High impact information on Siah1a

  • Activation of macrophages by endotoxin and of neurons by glutamate elicits GAPDH-Siah1 binding, nuclear translocation and apoptosis, which are prevented by NO deletion [2].
  • S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding [2].
  • Surface expression and subcellular distribution of group I mGluRs were not detectably altered in the presence of Siah1a as assessed by immunoflourescence experiments with epitope tagged receptors and imaging of a GFP/mGluR fusion construct [3].
  • A role for Seven in Absentia Homolog (Siah1a) in metabotropic glutamate receptor signaling [3].
  • RESULTS: The effects of coexpression of Siah on group I mGluR signaling were examined using heterologous expression in rat sympathetic, superior cervical ganglion neurons [3].

References

  1. Localization of immunoreactivity for deleted in colorectal cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents. Osborne, P.B., Halliday, G.M., Cooper, H.M., Keast, J.R. Neuroscience (2005) [Pubmed]
  2. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Hara, M.R., Agrawal, N., Kim, S.F., Cascio, M.B., Fujimuro, M., Ozeki, Y., Takahashi, M., Cheah, J.H., Tankou, S.K., Hester, L.D., Ferris, C.D., Hayward, S.D., Snyder, S.H., Sawa, A. Nat. Cell Biol. (2005) [Pubmed]
  3. A role for Seven in Absentia Homolog (Siah1a) in metabotropic glutamate receptor signaling. Kammermeier, P.J., Ikeda, S.R. BMC neuroscience [electronic resource]. (2001) [Pubmed]
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