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Gene Review

sina  -  seven in absentia

Drosophila melanogaster

Synonyms: CG9949, Dmel\CG9949, E3 ubiquitin-protein ligase sina, SINA, Seven in absentia protein, ...
 
 
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Disease relevance of sina

 

High impact information on sina

  • Down-regulation requires the presence of Phyllopod (PHYL), which is induced by the RAS pathway, and Seven In Absentia (SINA) [2].
  • The sina transcription unit is located within the intron of a gene that encodes an R7 cell-specific opsin [3].
  • These data indicate that the sina gene product is necessary at a stage in the determination of R7 cell fate when R7 receives and interprets developmental signals from neighboring cells, and possibly acts by regulating gene expression [3].
  • The Drosophila seven in absentia (sina) gene is required for R7 photoreceptor cell formation during Drosophila eye development, where it functions within the Ras/Raf pathway and targets other proteins for degradation via associations with a ubiquitin-conjugating enzyme [1].
  • Loss of tramtrack gene activity results in ectopic R7 cell formation, even in a sina mutant background [4].
 

Biological context of sina

  • The murine genome contains several closely related sina homologues (Siah1A-D, Siah2) that are also likely to participate in ras signaling [5].
  • These findings, together with the high degree of sequence conservation between the Siah proteins and sina, suggest that the mammalian Siah proteins may also participate in signal transduction by some tyrosine kinases [6].
  • Evolution of gene position: chromosomal arrangement and sequence comparison of the Drosophila melanogaster and Drosophila virilis sina and Rh4 genes [7].
  • This result is in contrast to that seen with other enhancer trap lines that display expression in R7, and indicates that some aspect of R7 differentiation is independent of the genetic pathway(s) involving sevenless, boss and sina [8].
  • Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression [9].
 

Anatomical context of sina

 

Other interactions of sina

References

  1. p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. Matsuzawa, S., Takayama, S., Froesch, B.A., Zapata, J.M., Reed, J.C. EMBO J. (1998) [Pubmed]
  2. Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack. Li, S., Li, Y., Carthew, R.W., Lai, Z.C. Cell (1997) [Pubmed]
  3. seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye. Carthew, R.W., Rubin, G.M. Cell (1990) [Pubmed]
  4. Loss of tramtrack gene activity results in ectopic R7 cell formation, even in a sina mutant background. Lai, Z.C., Harrison, S.D., Karim, F., Li, Y., Rubin, G.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia. Holloway, A.J., Della, N.G., Fletcher, C.F., Largespada, D.A., Copeland, N.G., Jenkins, N.A., Bowtell, D.D. Genomics (1997) [Pubmed]
  6. Expression of Siah-2, a vertebrate homologue of Drosophila sina, in germ cells of the mouse ovary and testis. Della, N.G., Bowtell, D.D., Beck, F. Cell Tissue Res. (1995) [Pubmed]
  7. Evolution of gene position: chromosomal arrangement and sequence comparison of the Drosophila melanogaster and Drosophila virilis sina and Rh4 genes. Neufeld, T.P., Carthew, R.W., Rubin, G.M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  8. The presumptive R7 cell of the developing Drosophila eye receives positional information independent of sevenless, boss and sina. Mlodzik, M., Hiromi, Y., Goodman, C.S., Rubin, G.M. Mech. Dev. (1992) [Pubmed]
  9. Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression. Nemani, M., Linares-Cruz, G., Bruzzoni-Giovanelli, H., Roperch, J.P., Tuynder, M., Bougueleret, L., Cherif, D., Medhioub, M., Pasturaud, P., Alvaro, V., der Sarkissan, H., Cazes, L., Le Paslier, D., Le Gall, I., Israeli, D., Dausset, J., Sigaux, F., Chumakov, I., Oren, M., Calvo, F., Amson, R.B., Cohen, D., Telerman, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  10. Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina). Della, N.G., Senior, P.V., Bowtell, D.D. Development (1993) [Pubmed]
 
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