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Gene Review:

Fcna - ficolin A

Mus musculus

Synonyms: Collagen/fibrinogen domain-containing protein 1, Fcn1, Ficolin-1, Ficolin-A, Ficolin-alpha, ...

Fujimori, Y. et al., Liu, Y. et al., Endo, Y. et al., Runza, V.L. et al.

Endo, Nakazawa, Liu, Iwaki, Takahashi, Fujita, Nakata, Matsushita,

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High impact information on Fcna

Recombinant ficolin A, its splicing variant, and ficolin B showed multimeric structures and revealed binding to both N-acetylglucosamine and N-acetylgalactosamine [1].
In this study, we isolated the cDNA encoding a novel variant of ficolin A having a shorter collagen-like domain and a longer gap sequence, which was generated from the ficolin A gene by alternative splicing [1].
Immunoblot analysis using an anti-mouse ficolin-A antiserum showed that mouse ficolin-A is a plasma protein with binding activity to elastin and GlcNAc [2].
The other human ficolin, M-ficolin, is a non-serum-type ficolin that is expressed in monocytes [3].
The cell types that express ficolin A mRNA in both adult liver and spleen were identified as macrophages by in situ hybridization [3].

Biological context of Fcna

The amino acid sequence of mouse ficolin-A is 60.2, 59.8, 59.8, and 59.6% identical to those of porcine ficolin-alpha, -beta, human ficolin-1, and EBP-37/P35, respectively [2].
RT-PCR analysis showed that the expression pattern of ficolin A expression was closely similar to that of Masps, suggesting that these molecules may function in coordination as components of the lectin complement pathway [3].

Anatomical context of Fcna

In humans, two plasma ficolins have been identified and characterized, whereas a third cell-associated ficolin (M-ficolin) was found on monocyte surfaces [4].

Analytical, diagnostic and therapeutic context of Fcna

Molecular cloning and characterization of mouse ficolin-A [2].
Northern blot analysis showed that mRNA of mouse ficolin-A is highly expressed in liver and spleen [2].

References

Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP. Endo, Y., Nakazawa, N., Liu, Y., Iwaki, D., Takahashi, M., Fujita, T., Nakata, M., Matsushita, M. Immunogenetics (2005) [Pubmed]
Molecular cloning and characterization of mouse ficolin-A. Fujimori, Y., Harumiya, S., Fukumoto, Y., Miura, Y., Yagasaki, K., Tachikawa, H., Fujimoto, D. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse. Liu, Y., Endo, Y., Homma, S., Kanno, K., Yaginuma, H., Fujita, T. Mol. Immunol. (2005) [Pubmed]
Localization of the mouse defense lectin ficolin B in lysosomes of activated macrophages. Runza, V.L., Hehlgans, T., Echtenacher, B., Zähringer, U., Schwaeble, W.J., Männel, D.N. J. Endotoxin Res. (2006) [Pubmed]

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