High impact information on Fcnb

• Recombinant ficolin A, its splicing variant, and ficolin B showed multimeric structures and revealed binding to both N-acetylglucosamine and N-acetylgalactosamine [1].
• Interestingly, ficolin B specifically recognized sialic acid residues [1].
• Ficolin B exhibited a distinct ontogeny pattern that switched from embryonic liver to postnatal bone marrow and spleen [2].
• Localization of the mouse defense lectin ficolin B in lysosomes of activated macrophages [3].
• By using ficolin B-specific antibodies and confocal microscopy, we show that ficolin B is expressed within mouse peritoneal exudate macrophages and is co-localized with Lamp-1, a marker for lysosomes and late endosomes [3].

Biological context of Fcnb

• In addition, the data indicate that ficolin B expression is up-regulated upon macrophage activation [3].

Analytical, diagnostic and therapeutic context of Fcnb

• The cells that express ficolin B mRNA were identified as belonging to the myeloid cell lineage by magnetic sorting and by subsequent RT-PCR in bone marrow cells [2].

References