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Gene Review

CRYGA  -  crystallin, gamma A

Homo sapiens

Synonyms: CRY-g-A, CRYG1, CRYG5, Gamma-A-crystallin, Gamma-crystallin 5, ...
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Disease relevance of CRYGA

  • Sequencing of the coding regions of the CRYGA, B, C, and D genes showed the presence of a heterozygous C>A transversion in exon 2 of CRYGD that is associated with cataracts in this family [1].

High impact information on CRYGA


Biological context of CRYGA

  • Haplotyping indicated that the disease gene lay in the approximate 10 Mb physical interval between D2S1384 and D2S128, containing the gamma-crystallin gene (CRYGA-CRYGD) cluster on chromosome 2q33.3-q34 [7].
  • Assignment of the human gamma-crystallin gene cluster (CRYG) to the long arm of chromosome 2, region q33-36 [8].
  • The maximum lod score (7.19 at recombination fraction theta=0) was obtained for marker D2S2208 near the gamma-crystallin gene (CRYG) cluster [1].
  • A single base-pair change in the CRYGA gene has been shown, leading to a premature stop codon [9].
  • It appeared to be caused by a missense mutation in the CRYGD gene, further supporting the notion that alterations to CRYG play an important factor in human cataract formation [10].

Other interactions of CRYGA


  1. Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts. Nandrot, E., Slingsby, C., Basak, A., Cherif-Chefchaouni, M., Benazzouz, B., Hajaji, Y., Boutayeb, S., Gribouval, O., Arbogast, L., Berraho, A., Abitbol, M., Hilal, L. J. Med. Genet. (2003) [Pubmed]
  2. Linkage of polymorphic congenital cataract to the gamma-crystallin gene locus on human chromosome 2q33-35. Rogaev, E.I., Rogaeva, E.A., Korovaitseva, G.I., Farrer, L.A., Petrin, A.N., Keryanov, S.A., Turaeva, S., Chumakov, I., St George-Hyslop, P., Ginter, E.K. Hum. Mol. Genet. (1996) [Pubmed]
  3. Trinucleotide repeat polymorphism at the CRYG1 locus. Hearne, C.M., Todd, J.A. Nucleic Acids Res. (1991) [Pubmed]
  4. Mutation analysis of congenital cataracts in Indian families: identification of SNPS and a new causative allele in CRYBB2 gene. Santhiya, S.T., Manisastry, S.M., Rawlley, D., Malathi, R., Anishetty, S., Gopinath, P.M., Vijayalakshmi, P., Namperumalsamy, P., Adamski, J., Graw, J. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  5. A 5-base insertion in the gammaC-crystallin gene is associated with autosomal dominant variable zonular pulverulent cataract. Ren, Z., Li, A., Shastry, B.S., Padma, T., Ayyagari, R., Scott, M.H., Parks, M.M., Kaiser-Kupfer, M.I., Hejtmancik, J.F. Hum. Genet. (2000) [Pubmed]
  6. Genetic fine localization of the arrestin (S-antigen) gene 4 cM distal from D2S172. Valverde, D., Bayés, M., Martínez, I., Grinberg, D., Vilageliu, L., Balcells, S., Gonzàlez-Duarte, R., Baiget, M. Hum. Genet. (1994) [Pubmed]
  7. A missense mutation in the gammaD crystallin gene (CRYGD) associated with autosomal dominant "coral-like" cataract linked to chromosome 2q. Mackay, D.S., Andley, U.P., Shiels, A. Mol. Vis. (2004) [Pubmed]
  8. Assignment of the human gamma-crystallin gene cluster (CRYG) to the long arm of chromosome 2, region q33-36. Shiloh, Y., Donlon, T., Bruns, G., Breitman, M.L., Tsui, L.C. Hum. Genet. (1986) [Pubmed]
  9. Further genetic heterogeneity for autosomal dominant human sutural cataracts. Klopp, N., Héon, E., Billingsley, G., Illig, T., Wjst, M., Rudolph, G., Graw, J. Ophthalmic Res. (2003) [Pubmed]
  10. Special fasciculiform cataract caused by a mutation in the gammaD-crystallin gene. Shentu, X., Yao, K., Xu, W., Zheng, S., Hu, S., Gong, X. Mol. Vis. (2004) [Pubmed]
  11. Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter. Lengler, J., Krausz, E., Tomarev, S., Prescott, A., Quinlan, R.A., Graw, J. Nucleic Acids Res. (2001) [Pubmed]
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