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Gene Review:

Gabra3 - gamma-aminobutyric acid (GABA) A receptor,...

Mus musculus

Synonyms: GABA(A) receptor subunit alpha-3, Gabra-3, Gamma-aminobutyric acid receptor subunit alpha-3

Faust, C.J. et al., Laval, S.H. et al., Chatterjee, A. et al., Mu, W. et al., Derry, J.M. et al.

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High impact information on Gabra3

YACs were isolated from four genomic libraries by PCR or hybridization screening for the loci Gabra3, DXHX1104, F8a, DXHX52, DXBay2, L1cam, and Rsvp [1].
A 2.3-Mb yeast artificial chromosome contig spanning from Gabra3 to G6pd on the mouse X chromosome [1].
These findings provide strong support for the concept that the order of loci lying in the Cf-9 to Gabra3 segment of the X chromosome is highly conserved between human and mouse [2].
Both Fmr-1 and DXS296h were mapped into the same recombination interval as Gabra3 on the mouse X chromosome [2].
In addition, we have extended the mapping of the GABAA alpha 3-subunit receptor gene (Gabra3) [3].

Biological context of Gabra3

Most sites were in or just downstream of a region of 55 (mouse) and 25 (human) GA repeats in the proximal promoter, as revealed by genome walking of Gabra3 and the human gene GABRA3 [4].

Other interactions of Gabra3

Physical mapping of the loci Gabra3, DXPas8, CamL1, and Rsvp in a region of the mouse X chromosome homologous to human Xq28 [5].

Analytical, diagnostic and therapeutic context of Gabra3

Using pulsed-field gel electrophoresis, a 3 million-bp physical map containing the X-linked loci Gabra3, DXPas8, CamL1, and Rsvp has been constructed for a segment of the mouse X chromosome homologous to human Xq28 [5].

References

A 2.3-Mb yeast artificial chromosome contig spanning from Gabra3 to G6pd on the mouse X chromosome. Chatterjee, A., Faust, C.J., Molinari-Storey, L., Kiochis, P., Poustka, A., Herman, G.E. Genomics (1994) [Pubmed]
Mapping of FMR1, the gene implicated in fragile X-linked mental retardation, on the mouse X chromosome. Laval, S.H., Blair, H.J., Hirst, M.C., Davies, K.E., Boyd, Y. Genomics (1992) [Pubmed]
Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome. Derry, J.M., Barnard, P.J. Genomics (1991) [Pubmed]
The mouse GABA(A) receptor alpha3 subunit gene and promoter. Mu, W., Burt, D.R. Brain Res. Mol. Brain Res. (1999) [Pubmed]
Physical mapping of the loci Gabra3, DXPas8, CamL1, and Rsvp in a region of the mouse X chromosome homologous to human Xq28. Faust, C.J., Herman, G.E. Genomics (1991) [Pubmed]

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AgaP_AGAP011349	Anopheles gambiae str. PEST
GABRA3	Bos taurus
GABRA3	Canis lupus familiaris
Grd	Drosophila melanogaster
GABRA3	Gallus gallus
GABRA3	Homo sapiens
GABRA3	Macaca mulatta
Gabra3	Rattus norvegicus
gabra3	Xenopus (Silurana) tropicalis

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