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Gene Review

GABRA3  -  gamma-aminobutyric acid (GABA) A receptor,...

Homo sapiens

Synonyms: GABA(A) receptor subunit alpha-3, Gamma-aminobutyric acid receptor subunit alpha-3
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Psychiatry related information on GABRA3


High impact information on GABRA3

  • We report the physical linkage of the gene encoding one of the subunits of the GABAA receptor (GABRA3) to the polymorphic locus DXS374 on the human X chromosome at Xq28 [3].
  • X-linked manic depression and other psychiatric disorders have been mapped to this region, and thus GABRA3 is a potential candidate gene for these disorders [3].
  • Our findings suggest that the GABRA3 polymorphism may confer susceptibility to or may be in linkage disequilibrium with another gene involved in the genetic etiology of BPAD [4].
  • Since gamma-aminobutyric acid also modulates the release of prolactin, we examined the possible association between alleles of the GABRA3 (gamma-aminobutyric acid A3 receptor) gene and MS [5].
  • DESIGN: We examined the GABRA3 alleles of 189 subjects with MS who died of their disease [5].

Biological context of GABRA3

  • No differences in genotype frequencies between unipolar patients and healthy subjects were found for GABRA 3 (P = 0.08) [1].
  • We have carried out an association study between a dinucleotide repeat polymorphism in GABRA3 gene and manic-depressive illness in a Spanish population [6].
  • Since anticipation has been described in both disorders and the pattern of segregation may be autosomal as well as X-linked, we have searched for a possible involvement of two candidate genes which are located either on an autosome (SCA1) or on the X-chromosome (GABRA3) [7].

Other interactions of GABRA3

  • The genomic characterization of GLUR3 and GABRA3 will allow mutational analysis of these genes as candidates for other X-linked neurological disorders mapping to Xq25-Xq26 and Xq28 [8].
  • DESIGN: Polymorphisms located in genes that code for GABRA3, GABRA5 and GABRB3 subunits of the GABAA receptor were investigated using association and linkage strategies [9].
  • The results of our study indicate that GABRA 3 gene might also be involved in the genetic pathophysiology of unipolar major depressive disorder (at least in female patients), even if the findings do not support a predominant role of GABRA 3 [1].


  1. The gamma amino butyric acid (GABA) receptor alpha-3 subunit gene polymorphism in unipolar depressive disorder: a genetic association study. Henkel, V., Baghai, T.C., Eser, D., Zill, P., Mergl, R., Zwanzger, P., Schüle, C., Bottlender, R., Jäger, M., Rupprecht, R., Hegerl, U., Möller, H.J., Bondy, B. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004) [Pubmed]
  2. Lack of association between GABRA3 and unipolar affective disorder: a multicentre study. Massat, I., Souery, D., Del-Favero, J., Oruc, L., Jakovljevic, M., Folnegovic, V., Adolfsson, R., Kaneva, R., Papadimitriou, G., Dikeos, D., Jazin, E., Milanova, V., Van Broeckhoven, C., Mendlewicz, J. Int. J. Neuropsychopharmacol. (2001) [Pubmed]
  3. Physical linkage of a GABAA receptor subunit gene to the DXS374 locus in human Xq28. Bell, M.V., Bloomfield, J., McKinley, M., Patterson, M.N., Darlison, M.G., Barnard, E.A., Davies, K.E. Am. J. Hum. Genet. (1989) [Pubmed]
  4. Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study. Massat, I., Souery, D., Del-Favero, J., Oruc, L., Noethen, M.M., Blackwood, D., Thomson, M., Muir, W., Papadimitriou, G.N., Dikeos, D.G., Kaneva, R., Serretti, A., Lilli, R., Smeraldi, E., Jakovljevic, M., Folnegovic, V., Rietschel, M., Milanova, V., Valente, F., Van Broeckhoven, C., Mendlewicz, J. Mol. Psychiatry (2002) [Pubmed]
  5. Association between the gamma-aminobutyric acid A3 receptor gene and multiple sclerosis. Gade-Andavolu, R., MacMurray, J.P., Blake, H., Muhleman, D., Tourtellotte, W., Comings, D.E. Arch. Neurol. (1998) [Pubmed]
  6. Lack of association between manic-depressive illness and a highly polymorphic marker from GABRA3 gene. Puertollano, R., Visedo, G., Saiz-Ruiz, J., Llinares, C., Fernández-Piqueras, J. Am. J. Med. Genet. (1995) [Pubmed]
  7. Familial cosegregation of manic-depressive illness and a form of hereditary cerebellar ataxia. Fernández Piqueras, J., Santos, J., Visedo, G., Pérez de Castro, I., Puertollano, R., Montejo, J., Ramo Tello, C., Valle, J. Am. J. Med. Genet. (1995) [Pubmed]
  8. Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq. Amir, R., Dahle, E.J., Toriolo, D., Zoghbi, H.Y. Am. J. Med. Genet. (2000) [Pubmed]
  9. Association and linkage studies of candidate genes involved in GABAergic neurotransmission in lithium-responsive bipolar disorder. Duffy, A., Turecki, G., Grof, P., Cavazzoni, P., Grof, E., Joober, R., Ahrens, B., Berghöfer, A., Müller-Oerlinghausen, B., Dvoráková, M., Libigerová, E., Vojtĕchovský, M., Zvolský, P., Nilsson, A., Licht, R.W., Rasmussen, N.A., Schou, M., Vestergaard, P., Holzinger, A., Schumann, C., Thau, K., Robertson, C., Rouleau, G.A., Alda, M. Journal of psychiatry & neuroscience : JPN. (2000) [Pubmed]
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