High impact information on E2F7

• Consistent with being an E2F target gene, we found that the expression of E2F7 is cell cycle regulated [1].
• Like the recently identified E2F-like proteins of Arabidopsis, E2F7 has two DNA binding domains and binds to the E2F DNA binding consensus site independently of DP co-factors [1].
• Furthermore, E2F7 associates with E2F-regulated promoters in vivo, and this association increases in S phase [1].
• Similar to E2F7, overexpression of E2F8 significantly slows down the proliferation of primary mouse embryonic fibroblasts [2].
• These observations, together with the fact that E2F7 and E2F8 can homodimerize and are expressed in the same adult tissues, suggest that they may have overlapping and perhaps synergistic roles in the control of cellular proliferation [2].

Biological context of E2F7

• Furthermore, down-regulation of E2F7 may contribute to mechanisms underlying platinum resistance, and calculation of ratios of proliferation-promoting E2F1 to E2F7 could serve as a putative predictor of platinum resistance [3].
• First, the E2F7 gene encodes a protein that possesses two distinct DNA-binding domains and that lacks a dimerization domain as well as a transcriptional activation and a retinoblastoma-binding domain [4].

Other interactions of E2F7

• Again, ratios of E2F1 or E2F2 to E2F7 were the most favorable variables in predicting platinum resistance [3].

References